Roles of PDGF in animal development

被引：447
作者：
Hoch, RV
Soriano, P
机构：
[1] Fred Hutchinson Canc Res Ctr, Program Dev Biol, Seattle, WA 98109 USA
[2] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA
来源：
DEVELOPMENT | 2003年 / 130卷 / 20期
关键词：
GROWTH-FACTOR RECEPTOR; FACTOR-ALPHA-RECEPTOR; SMOOTH-MUSCLE-CELLS; NEURAL CREST CELLS; ZEBRAFISH EMBRYONIC-DEVELOPMENT; PROTEASE-ACTIVATED LIGAND; CENTRAL-NERVOUS-SYSTEM; SIMIAN SARCOMA-VIRUS; FACTOR-A-CHAIN; IN-VIVO;
D O I：
10.1242/dev.00721
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Recent advances in genetic manipulation have greatly expanded our understanding of cellular responses to platelet-derived growth factors (PDGFs) during animal development. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialized mesenchymal and migratory cell types, both during development and in the adult animal. Furthermore, the availability of genomic sequence data has facilitated the identification of novel PDGF and PDGF receptor (PDGFR) family members in C elegans, Drosophila, Xenopus, zebrafish and mouse. Early data from these different systems suggest that some functions of PDGFs have been evolutionarily conserved.
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收藏
页码：4769 / 4784
页数：16
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