Self-assembled multifunctional core-shell highly porous metal-organic framework nanoparticles

被引:10
作者
Qiu, Jingwen [1 ]
Li, Xue [1 ]
Steenkeste, Karine [1 ]
Barroca-Aubry, Nadine [2 ]
Aymes-Chodur, Caroline [2 ]
Roger, Philippe [2 ]
Casas-Solvas, Juan M. [3 ]
Vargas-Berenguel, Antonio [3 ]
Rihouey, Christophe [4 ]
Picton, Luc [4 ]
Gref, Ruxandra [1 ]
机构
[1] Univ Paris Saclay, Inst Sci Mol Orsay, CNRS, Orsay 91405, France
[2] Univ Paris Saclay, Inst Chim Mol & Mat Orsay, CNRS, Orsay 91405, France
[3] Univ Almeria, Dept Quim & Fis, Almeria 04120, Spain
[4] Normandie Univ, UNIROUEN, Polymeres Biopolymerus Surfaces, Inst Natl Sci Appl Rouen,CNRS,UMR 6270, Mont St Aignan 76821, France
基金
欧洲研究理事会;
关键词
Metal organic frameworks; gamma-cyclodextrin-citrate oligomers; Surface modification; Doxorubicin; Self assemble; HOST-GUEST INTERACTIONS; MOF NANOPARTICLES; CITRIC-ACID; CYCLODEXTRIN; DOXORUBICIN; OLIGOMERS; DELIVERY; CARRIERS;
D O I
10.1016/j.ijpharm.2020.119281
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Core-shell nanoparticles (NPs) are attracting increasing interest in nanomedicine as they exhibit unique properties arising from the combined assets of core and shell materials. Porous nanoscale metal-organic frameworks (nanoMOFs) are able to incorporate with high payloads a large variety of drugs. Like other types of NPs, nanoMOFs need to be functionalized with engineered coatings to ensure colloidal stability, control in vivo fate and drug release. To do so, a novel biodegradable cyclodextrin (CD)-based shell was designed in this study. Water soluble gamma-CD-citrate oligomers grafted or not with fluorophores were successfully synthesized using citric acid as crosslinker and efficiently anchored onto the surface of porous nanoMOFs. As compared to monomeric CDs, the oligomeric CD coatings could offer higher interaction possibilities with the cores and better possibilities to graft functional moieties such as fluorescent molecules. The amounts of gamma-CD-citrate oligomers onto the nanoMOFs were as high as 53 +/- 8 wt%. The yield reached up to 86% in the optimized system. These core-shell nanocomposites were stable upon storage, in contrast to the naked nanoMOFs. In addition, the presence of the coating prevented the doxorubicin (DOX)-loaded nanoMOFs from aggregation. Moreover, due to the presence of fluorophores conjugated to the shell, fluorescence-lifetime microscopy enabled deciphering the coating mechanism. DOX loadings reached 48 +/- 10 wt% after 24 h incubation with the drug solution. After coating for additional 24 h, DOX loadings reached 65 +/- 8 wt%.
引用
收藏
页数:10
相关论文
共 50 条
  • [21] Ni-Based Metal-Organic Framework Nanorods Self-assembled into Hollow Architecture and Decorated with Pt Nanoparticles as Nanocatalysts for CO Oxidation
    Srinivasapriyan, Vijayan
    Huang, Zhongliang
    Song, Miaomiao
    Zeng, Xiaoli
    Xiao, Jingran
    Zhou, Shu-Feng
    Zhan, Guowu
    [J]. ACS APPLIED NANO MATERIALS, 2021, 4 (05) : 4356 - 4360
  • [22] Multifunctional core-shell nanoparticles: superparamagnetic, mesoporous, and thermosensitive
    Ye, Fei
    Qin, Jian
    Toprak, Muhammet S.
    Muhammed, Mamoun
    [J]. JOURNAL OF NANOPARTICLE RESEARCH, 2011, 13 (11) : 6157 - 6167
  • [23] Metal-Organic Framework Nanoparticles
    Wang, Shunzhi
    McGuirk, C. Michael
    d'Aquino, Andrea
    Mason, Jarad A.
    Mirkin, Chad A.
    [J]. ADVANCED MATERIALS, 2018, 30 (37)
  • [24] Self-assembled core-shell Fe3O4@SiO2 nanoparticles from electrospun fibers
    Zhang, Pei-pei
    Wang, Bin
    Williams, Gareth R.
    Branford-White, Christopher
    Quan, Jing
    Nie, Hua-li
    Zhu, Li-min
    [J]. MATERIALS RESEARCH BULLETIN, 2013, 48 (09) : 3058 - 3064
  • [25] Core-shell metal-organic framework/silica hybrid with tunable shell structure as stationary phase for high performance liquid chromatography
    Wang, Jiafei
    He, Yuqing
    Wan, Xiang
    Xie, Fazhi
    Sun, Yuanshe
    Li, Tong
    Xu, Qin
    Zhao, Donglin
    Qu, Qishu
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2023, 1705
  • [26] Magnetic responsive metal-organic frameworks nanosphere with core-shell structure for highly efficient removal of methylene blue
    Shao, Yanming
    Zhou, Lincheng
    Bao, Chao
    Ma, Junjun
    Liu, Mingzhu
    Wang, Fei
    [J]. CHEMICAL ENGINEERING JOURNAL, 2016, 283 : 1127 - 1136
  • [27] A chiral metal-organic framework core-shell microspheres composite for high-performance liquid chromatography enantioseparation
    Chen, Ji-Kai
    Xu, Na-Yan
    Guo, Ping
    Wang, Bang-Jin
    Zhang, Jun-Hui
    Xie, Sheng-Ming
    Yuan, Li-Ming
    [J]. JOURNAL OF SEPARATION SCIENCE, 2021, 44 (21) : 3976 - 3985
  • [28] Core-Shell Metal-Organic Frameworks/Molecularly Imprinted Nanoparticles as Absorbents for the Detection of Pyrraline in Milk and Milk Powder
    Liu, Huilin
    Mu, Lin
    Chen, Xiaomo
    Wang, Jing
    Wang, Shuo
    Sun, Baoguo
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017, 65 (04) : 986 - 992
  • [29] Electrodeposited metal-organic framework films as self-assembled hierarchically superstructured supports for stable omniphobic surface coatings
    Jakob Sablowski
    Julia Linnemann
    Simone Hempel
    Volker Hoffmann
    Simon Unz
    Michael Beckmann
    Lars Giebeler
    [J]. Scientific Reports, 8
  • [30] Oxygen Self-Sufficient Core-Shell Metal-Organic Framework-Based Smart Nanoplatform for Enhanced Synergistic Chemotherapy and Photodynamic Therapy
    Ren, Shen-Zhen
    Wang, Bin
    Zhu, Xiao-Hua
    Zhu, Dan
    Liu, Ming
    Li, Shu-Kai
    Yang, Yu-Shun
    Wang, Zhong-Chang
    Zhu, Hai-Liang
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2020, 12 (22) : 24662 - 24674