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Self-assembled multifunctional core-shell highly porous metal-organic framework nanoparticles
被引:10
作者:
Qiu, Jingwen
[1
]
Li, Xue
[1
]
Steenkeste, Karine
[1
]
Barroca-Aubry, Nadine
[2
]
Aymes-Chodur, Caroline
[2
]
Roger, Philippe
[2
]
Casas-Solvas, Juan M.
[3
]
Vargas-Berenguel, Antonio
[3
]
Rihouey, Christophe
[4
]
Picton, Luc
[4
]
Gref, Ruxandra
[1
]
机构:
[1] Univ Paris Saclay, Inst Sci Mol Orsay, CNRS, Orsay 91405, France
[2] Univ Paris Saclay, Inst Chim Mol & Mat Orsay, CNRS, Orsay 91405, France
[3] Univ Almeria, Dept Quim & Fis, Almeria 04120, Spain
[4] Normandie Univ, UNIROUEN, Polymeres Biopolymerus Surfaces, Inst Natl Sci Appl Rouen,CNRS,UMR 6270, Mont St Aignan 76821, France
基金:
欧洲研究理事会;
关键词:
Metal organic frameworks;
gamma-cyclodextrin-citrate oligomers;
Surface modification;
Doxorubicin;
Self assemble;
HOST-GUEST INTERACTIONS;
MOF NANOPARTICLES;
CITRIC-ACID;
CYCLODEXTRIN;
DOXORUBICIN;
OLIGOMERS;
DELIVERY;
CARRIERS;
D O I:
10.1016/j.ijpharm.2020.119281
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Core-shell nanoparticles (NPs) are attracting increasing interest in nanomedicine as they exhibit unique properties arising from the combined assets of core and shell materials. Porous nanoscale metal-organic frameworks (nanoMOFs) are able to incorporate with high payloads a large variety of drugs. Like other types of NPs, nanoMOFs need to be functionalized with engineered coatings to ensure colloidal stability, control in vivo fate and drug release. To do so, a novel biodegradable cyclodextrin (CD)-based shell was designed in this study. Water soluble gamma-CD-citrate oligomers grafted or not with fluorophores were successfully synthesized using citric acid as crosslinker and efficiently anchored onto the surface of porous nanoMOFs. As compared to monomeric CDs, the oligomeric CD coatings could offer higher interaction possibilities with the cores and better possibilities to graft functional moieties such as fluorescent molecules. The amounts of gamma-CD-citrate oligomers onto the nanoMOFs were as high as 53 +/- 8 wt%. The yield reached up to 86% in the optimized system. These core-shell nanocomposites were stable upon storage, in contrast to the naked nanoMOFs. In addition, the presence of the coating prevented the doxorubicin (DOX)-loaded nanoMOFs from aggregation. Moreover, due to the presence of fluorophores conjugated to the shell, fluorescence-lifetime microscopy enabled deciphering the coating mechanism. DOX loadings reached 48 +/- 10 wt% after 24 h incubation with the drug solution. After coating for additional 24 h, DOX loadings reached 65 +/- 8 wt%.
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页数:10
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