Cephalotane-Type Norditerpenoids from Cephalotaxus fortunei var. alpina

被引：29
作者：
Ge, Zhan-Peng [1 ]
Zhou, Bin [1 ]
Zimbres, Flavia M. [2 ]
Cassera, Maria B. [2 ]
Zhao, Jin-Xin [1 ]
Yue, Jian-Min [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
[2] Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Dept Biochem & Mol Biol, Athens, GA 30602 USA
来源：
CHINESE JOURNAL OF CHEMISTRY | 2022年 / 40卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Cephalotaxus fortunei var; alpine; Natural products; Structural elucidation; Cephalotane norditerpenoids; Antimalarial activity; A-D;
D O I：
10.1002/cjoc.202100913
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Comprehensive Summary A chemical investigation of the 95% EtOH extract of the seeds of Cephalotaxus fortunei var. alpina led to the isolation of nine new cephalotane-type norditerpenoids, ceforalides A-I (1-9), and two known analogues (10 and 11). Compounds 1-8 belong to a rare class of A-ring-contracted cephalotane-type norditerpenoids, of which compound 8 incorporates a unique tetrasubstituted 2,5-cyclohexadienone A-ring. Compound 9 is a rare 13,14-seco-17-nor-cephalotane-type diterpenoid. Their structures were determined based on NMR, HRESIMS, ECD, and X-ray diffraction analysis. Biological tests revealed compounds 10 and 11 displayed moderate antimalarial activity.
引用
收藏
页码：1177 / 1184
页数：8
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