The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication

被引：35

作者：

Davarinejad, Hossein ^{[1
]}

Huang, Yi-Chun ^{[2
]}

Mermaz, Benoit ^{[2
]}

LeBlanc, Chantal ^{[2
]}

Poulet, Axel ^{[2
]}

Thomson, Geoffrey ^{[2
]}

Joly, Valentin ^{[2
]}

Munoz, Marcelo ^{[3
,4
]}

Arvanitis-Vigneault, Alexis ^{[1
]}

Valsakumar, Devisree ^{[5
,6
]}

Villarino, Gonzalo ^{[2
]}

Ross, Alex ^{[3
,4
]}

Rotstein, Benjamin H. ^{[4
,7
]}

Alarcon, Emilio, I ^{[3
,4
]}

Brunzelle, Joseph S. ^{[8
]}

Voigt, Philipp ^{[5
,6
]}

Dong, Jie ^{[2
,9
]}

Couture, Jean-Francois ^{[1
]}

Jacob, Yannick ^{[2
]}

机构：

[1] Univ Ottawa, Fac Med, Ottawa Inst Syst Biol, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06511 USA

[3] Univ Edinburgh, Wellcome Ctr Cell Biol, Sch Biol Sci, Edinburgh EH9 3BF, Midlothian, Scotland

[4] Babraham Inst, Epigenet Programme, Cambridge CB22 3AT, England

[5] Univ Ottawa, Div Cardiac Surg, BEaTS Res Lab, Heart Inst, Ottawa, ON K1Y 4W7, Canada

[6] Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

[7] Univ Ottawa, Heart Inst, Ottawa, ON K1Y 4W7, Canada

[8] Northwestern Univ, Feinberg Sch Med, Dept Mol Pharmacol & Biol Chem, Chicago, IL 60611 USA

[9] Zhejiang Univ, Inst Crop Sci, Hangzhou 310058, Peoples R China

来源：

SCIENCE | 2022年 / 375卷 / 6586期

基金：

英国惠康基金; 加拿大健康研究院; 英国生物技术与生命科学研究理事会;

关键词：

MMS22L-NFKBIL2; COMPLEX; MMS22L-TONSL COMPLEX; ARABIDOPSIS GENE; READ ALIGNMENT; CELL-CYCLE; RECRUITS; RECOMBINATION; METHYLATION; EXPRESSION; TELOMERES;

D O I：

10.1126/science.abm5320

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The tail of replication-dependent histone H3.1 varies from that of replication-independent H3.3 at the amino acid located at position 31 in plants and animals, but no function has been assigned to this residue to demonstrate a unique and conserved role for H3.1 during replication. We found that TONSOKU (TSK/TONSL), which rescues broken replication forks, specifically interacts with H3.1 via recognition of alanine 31 by its tetratricopeptide repeat domain. Our results indicate that genomic instability in the absence of ATXR5/ATXR6-catalyzed histone H3 lysine 27 monomethylation in plants depends on H3.1, TSK, and DNA polymerase theta (Pol theta). This work reveals an H3.1-specific function during replication and a common strategy used in multicellular eukaryotes for regulating post-replicative chromatin maturation and TSK, which relies on histone monomethyltransferases and reading of the H3.1 variant.

引用

页码：1281 / +

页数：37

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