Use of asymmetric propargyl dicobalt hexacarbonyl complexes in organic synthesis:: Access to enantiomerically pure α-hydroxy acid derivatives

被引：18

作者：

Betancort, JM ^{[1
]}

Rodríguez, CM ^{[1
]}

Martín, VS ^{[1
]}

机构：

[1] Univ La Laguna, CSIC, Inst Univ Bioorgan Antonio Gonzalez, E-38206 La Laguna, Tenerife, Spain

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 52期

关键词：

Nicholas reaction; asymmetric synthesis;

D O I：

10.1016/S0040-4039(98)02170-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The trapping under different conditions of the carbocation generated by acid treatment of chiral Co-2(CO)(6)-complexed propargylic secondary alcohols permitted access to either diastereoisomer at the propargylic center. Further chemical manipulations provided either enantiomer of enantiomerically pure 1,2-difunctionalized molecules such as 1,2-diols, alpha-hydroxy-aldehydes or alpha-hydroxy-acids. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9773 / 9776

页数：4

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