Lipid peroxidation induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system

被引：0

作者：

Bin Kwon, O ^{[1
]}

Kang, JH ^{[1
]}

机构：

[1] Chongju Univ, Dept Energy Engn, Chonju 360764, South Korea

来源：

BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL | 1999年 / 47卷 / 04期

关键词：

copper; zinc-superoxide dismutase; hydroxyl radical; lipid peroxidation; free copper;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cu,Zn-superoxide dismutase (SOD) can catalyze hydroxyl radical generation using H2O2 as a substrate. Lipid peroxidation induced by the Cu,Zn-SOD and H2O2 system was investigated. When linoleic acids micelles or phosphatidylcholine liposomes were incubated with Cu,Zn-SOD and H2O2, lipid peroxidation was gradually increased in a time-dependent manner. The extent of lipid peroxidation was proportional to Cu,Zn-SOD and H2O2 concentrations. Hydroxyl radical scavengers and copper chelator inhibited lipid peroxidation induced by the Cu,Zn-SOD and H2O2 system. These results suggest that lipid peroxidation is mediated by the Cu,Zn-SOD and H2O2 system via the generation of hydroxyl radicals by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper released from oxidatively damaged SOD.

引用

页码：645 / 653

页数：9

共 21 条

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