Synthesis and binding affinities of 2β-(3-iodoallyloxycarbonyl)3β-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies

被引：3
作者：
Chung, KH
Lim, CH
Lee, DR
Jin, CB
Chi, DY
机构：
[1] Inha Univ, Dept Chem, Nam Gu, Inchon 402751, South Korea
[2] Future Chem Co, Nam Gu, Inchon 402751, South Korea
[3] Korea Inst Sci & Technol, Bioanalysis & Biotransformat Res Ctr, Seoul 130650, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 23期
关键词：
D O I：
10.1016/S0960-894X(01)00625-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Tropane analogues from cocaine, which is known to be one of the most reinforcing and addictive compounds, were designed, synthesized, and characterized for inhibition of presynaptic uptake of dopamine (DA) in brain. Eight new derivatives of 3 beta -aryl-2 beta-(3-iodoallyloxycarbonyl)tropanes were synthesized and tested for their potential abilities to displace [H-3]2 beta -carbomethoxy-3 beta-(4-fluorophenyl)tropane (WIN 35,428) binding to the rat striatal membranes. (C) 2001 Elsevier Science Ltd. All rights reserved.
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收藏
页码：3077 / 3080
页数：4
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