Protecting-Group-Free Total Synthesis of (-)-Boscartin A in 3 Steps from (-)-Boscartin F via Wharton Reaction

被引：1

作者：

Kamo, Shogo ^{[1
]}

Kasamatsu, Akihiko ^{[1
]}

Shiraiwa, Junya ^{[1
]}

Matsuzawa, Akinobu ^{[1
]}

Sugita, Kazuyuki ^{[1
]}

机构：

[1] Hoshi Univ, Dept Synthet Med Chem, Fac Pharmaceut Sci, 2-4-41 Ebara,Shinagawa Ku, Tokyo 1428501, Japan

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 2022卷 / 47期

关键词：

boscartin A; enantioselective; protecting-group-free; total synthesis; Wharton reaction; SOFT; CEMBRANOIDS; STEREOCHEMISTRY; DITERPENOIDS; RESIN;

D O I：

10.1002/ejoc.202201366

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this report, we described the first total synthesis of (-)-boscartin A, a cembranoid featuring a 5/5/12-fused tricyclic structure. Via the key reactions, including stereoselective epoxidation and Wharton reaction, (-)-Boscartin A was obtained in three steps from (-)-boscartin F, with 46 % overall yield.

引用

页数：3

共 22 条

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