Phenobarbital and Temperature Profile During Hypothermia for Hypoxic-Ischemic Encephalopathy

被引：19

作者：

Sant'Anna, Guilherme ^{[1
]}

Laptook, Abbot R. ^{[2
]}

Shankaran, Seetha ^{[3
]}

Bara, Rebecca ^{[3
]}

McDonald, Scott A. ^{[4
]}

Higgins, Rosemary D. ^{[5
]}

Tyson, Jon E. ^{[6
]}

Ehrenkranz, Richard A. ^{[7
]}

Das, Abhik ^{[4
]}

Goldberg, Ronald N. ^{[8
]}

Walsh, Michele C. ^{[9
]}

机构：

[1] McGill Univ, Div Neonatol, Dept Pediat, Ctr Hlth, Montreal, PQ H3H 1P3, Canada

[2] Brown Univ, Providence, RI 02912 USA

[3] Wayne State Univ, Sch Med, Detroit, MI USA

[4] RTI Int, Dept Stat & Epidemiol, Res Triangle Pk, NC USA

[5] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA

[6] Univ Texas Houston, Houston, TX USA

[7] Yale Univ, New Haven, CT USA

[8] Duke Univ, Durham, NC USA

[9] Case Western Reserve Univ, Cleveland, OH 44106 USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2012年 / 27卷 / 04期

基金：

美国国家卫生研究院;

关键词：

phenobarbital; hypoxic-ischemic encephalopathy; hypothermia; temperature control; anticonvulsant; seizures; barbiturates; WHOLE-BODY HYPOTHERMIA; NEONATAL ENCEPHALOPATHY; REGULATED HYPOTHERMIA; BRAIN-INJURY; SYSTEMIC HYPOTHERMIA; OXYGEN-CONSUMPTION; NEWBORN RATS; THERMOGENESIS; MANAGEMENT; ASPHYXIA;

D O I：

10.1177/0883073811419317

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Data from the whole-body hypothermia trial was analyzed to examine the effects of phenobarbital administration prior to cooling (+PB) on the esophageal temperature (T-e) profile, during the induction phase of hypothermia. A total of 98 infants were analyzed. At enrollment, +PB infants had a higher rate of severe hypoxic-ischemic encephalopathy and clinical seizures and lower T-e and cord pH than infants that have not received phenobarbital (-PB). There was a significant effect of phenobarbital itself and an interaction between phenobarbital and time in the T-e profile. Mean T-e in the +PB group was lower than in the -PB group, and the differences decreased over time. In +PB infants, the time to surpass target T-e of 33.5 degrees C and to reach the minimum T-e during overshoot were shorter. In conclusion, the administration of phenobarbital before cooling was associated with changes that may reflect a reduced thermogenic response associated with barbiturates.

引用

页码：451 / 457

页数：7

共 36 条

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