Clinical characteristics associated with the prescribing of SSRI medication in adolescents with major unipolar depression

被引：9

作者：

Cousins, Lesley ^{[1
,9
]}

Whitaker, Kirstie J. ^{[1
]}

Widmer, Barry ^{[1
]}

Midgley, Nick ^{[2
,8
]}

Byford, Sarah ^{[3
]}

Dubicka, Bernadka ^{[4
,10
]}

Kelvin, Raphael ^{[1
,9
]}

Reynolds, Shirley ^{[5
]}

Roberts, Christopher ^{[6
]}

Holland, Fiona ^{[6
]}

Barrett, Barbara ^{[3
]}

Senior, Robert ^{[7
]}

Wilkinson, Paul ^{[1
,9
]}

Target, Mary ^{[2
,8
]}

Fonagy, Peter ^{[2
,8
]}

Goodyer, Ian M. ^{[1
,9
]}

机构：

[1] Univ Cambridge, Dev Psychiat Sect, Douglas House,18b Trumpington Rd, Cambridge CB2 8AH, England

[2] UCL, Anna Freud Ctr, London, England

[3] Kings Coll London, Ctr Econ Mental & Phys Hlth, London, England

[4] Univ Manchester, Inst Brain & Behav & Mental Hlth, Manchester, Lancs, England

[5] Univ East Anglia, Sch Med, Norwich, Norfolk, England

[6] Univ Manchester, Inst Populat Hlth, Biostat Grp, Manchester, Lancs, England

[7] Tavistock & Portman NHS Fdn Trust, Tavistock Ctr, London, England

[8] UCL, Res Dept Clin Educ & Hlth Psychol, London, England

[9] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England

[10] Lancashire Care Fdn Trust, Preston, Lancs, England

来源：

EUROPEAN CHILD & ADOLESCENT PSYCHIATRY | 2016年 / 25卷 / 12期

关键词：

Adolescents; Depression; Antidepressants; SSRIs; Risk; Self-harm; RANDOMIZED CONTROLLED-TRIAL; MENTAL-HEALTH; SELF-HARM; CHILDREN; DISORDERS; QUESTIONNAIRE; OUTCOMES; THERAPY; HONOSCA; EUROQOL;

D O I：

10.1007/s00787-016-0849-y

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Unipolar major depressions (MD) emerge markedly during adolescence. National Institute for Health and Care Excellence (NICE) UK recommends psychological therapies, with accompanying selective serotonin reuptake inhibitors (SSRIs) prescribed in severe cases only. Here, we seek to determine the extent and rationale of SSRI prescribing in adolescent MD before entering a randomised clinical trial. SSRI prescribing, together with their clinical characteristics was determined in 465 adolescent patients with MD prior to receiving a standardised psychological therapy as part of the Improving mood with psychoanalytic and cognitive therapies (IMPACT) clinical trial. Overall, 88 (19 %) had been prescribed antidepressants prior to psychological treatment. The clinical correlates varied by gender: respectively, depression severity in boys and self-harming behaviours in girls. Prescribing also differed between clinical research centres. Medical practitioners consider severity of depression in boys as an indicator for antidepressant prescribing. Self-injury in girls appears to be utilised as a prescribing aid which is inconsistent with past and current revised UK NICE guidelines.

引用

页码：1287 / 1295

页数：9

共 24 条

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