Functional MRI of sleep spindles and K-complexes

被引：69

作者：

Caporro, Matteo ^{[2
]}

Haneef, Zulfi ^{[3
]}

Yeh, Hsiang J. ^{[1
]}

Lenartowicz, Agatha ^{[4
]}

Buttinelli, Carla ^{[2
]}

Parvizi, Josef ^{[5
]}

Stern, John M. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA

[2] Univ Roma La Sapienza, Dept Neurol, Rome, Italy

[3] Drexel Univ, Dept Neurol, Philadelphia, PA 19104 USA

[4] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA

[5] Stanford Univ, Dept Neurol, Stanford, CA 94305 USA

来源：

CLINICAL NEUROPHYSIOLOGY | 2012年 / 123卷 / 02期

关键词：

Electroencephalography (EEG); Functional MRI (fMRI); Spindles; K-complexes; Sleep; Non-REM; FMRI; EEG; ACTIVATION; CORTEX;

D O I：

10.1016/j.clinph.2011.06.018

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Sleep spindles and K-complexes are EEG hallmarks of non-REM sleep. However, the brain regions generating these discharges and the functional connections of their generators to other regions are not fully known. We investigated the neuroanatomical correlates of spindles and K-complexes using simultaneous EEG and fMRI. Methods: EEGs recorded during EEG-fMRI studies of 7 individuals were used for fMRI analysis. Higher-level group analyses were performed, and images were thresholded at Z >= 2.3. Results: fMRI of 106 spindles and 60 K-complexes was analyzed. Spindles corresponded to increased signal in thalami and posterior cingulate, and right precuneus, putamen, paracentral cortex, and temporal lobe. K-complexes corresponded to increased signal in thalami, superior temporal lobes, paracentral gyri, and medial regions of the occipital, parietal and frontal lobes. Neither corresponded to regions of decreased signal. Conclusions: fMRI of both spindles and K-complexes depicts signal subjacent to the vertex, which likely indicates each discharges' source. The thalamic signal is consistent with thalamic involvement in sleep homeostasis. The limbic region's signal is consistent with roles in memory consolidation. Unlike the spindle, the K-complex corresponds to extensive signal in primary sensory cortices. Significance: Identification of these active regions contributes to the understanding of sleep networks and the physiology of awareness and memory during sleep. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：303 / 309

页数：7