Failure of beta-cell function to compensate lack of insulin action in hyperuricemic subjects

被引:11
作者
Simental-Mendia, Luis E. [1 ,2 ]
Rodriguez-Moran, Martha [1 ,2 ]
Guerrero-Romero, Fernando [1 ]
机构
[1] Mexican Social Secur Inst, Biomed Res Unit, Durango, Mexico
[2] Res Grp Diabet & Chron Illnesses, Durango, Mexico
关键词
uric acid; beta-cell function; insulin sensitivity; IGT; SERUM URIC-ACID; CARDIOVASCULAR RISK-FACTORS; IMPAIRED GLUCOSE-TOLERANCE; METABOLIC-SYNDROME; ATHEROSCLEROSIS RISK; SENSITIVITY; RESISTANCE; MEN; HOMEOSTASIS; PROGRESSION;
D O I
10.1002/dmrr.988
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Elevated serum uric acid has been related to insulin resistance, but there are no studies regarding its association with beta-cell function. In this study, we examine the response of beta-cell function to compensate insulin resistance in hyperuricaemic subjects. Methods Population-based cross-sectional study. A total of 212 healthy individuals, men and non-pregnant women, aged 20-65 years, were randomly recruited and allocated into groups with hyperuricaemia or normouricaemia that were matched by value of Belfiore index. Hyperuricaemia was defined by serum uric acid concentration >= 416 mu mol/L in men and >= 357 mu mol/L in women. To evaluate the compensation of insulin secretion to variation of insulin sensitivity, we used a surrogate of the hyperbolic model of beta-cell function based on Belfiore and Homeostasis Model Analysis beta-cell (HOMA-beta) indexes; the area under curves (AUC) was calculated. The association between the uric acid levels and the AUC was estimated using a multivariate regression analysis adjusted by age, sex, and waist circumference. Results Hyperuricaemia was identified in 77 (36.3%) individuals. A total of 39 (50.6%) hyperuricaemic and 44 (32.6%) normouricaemic subjects had diagnosis of impaired glucose tolerance (IGT), p = 0.01. In the total population, the AUCs in the hyperuricaemic and normouricaemic groups were 1.60725 cm(2) and 3.9819 cm(2), respectively (odds ratio [OR] 3.9; CI 95% 1.4-8.9). Among the 83 individuals with IGT, the AUCs in the subgroups with and without hyperuricaemia were 0.8495 cm(2) and 2.42075 cm(2), respectively (OR 2.7; CI 95% 1.3-10.1). Conclusions Our results show the failure of beta-cell function to compensate variation of insulin sensitivity in the hyperuricaemic individuals. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码:535 / 541
页数:7
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