Tumor cell metabolism imaging

被引：222

作者：

Plathow, Christian ^{[1
,2
]}

Weber, Wolfgang A. ^{[1
]}

机构：

[1] Univ Freiburg, Dept Nucl Med, D-79106 Freiburg, Germany

[2] German Canc Res Ctr, Dept Radiol, D-6900 Heidelberg, Germany

来源：

JOURNAL OF NUCLEAR MEDICINE | 2008年 / 49卷

关键词：

glucose metabolism; amino acid metabolism; lipid metabolism; PET; optical imaging; MRI;

D O I：

10.2967/jnumed.107.045930

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Molecular imaging of tumor metabolism has gained considerable interest, since preclinical studies have indicated a close relationship between the activation of various oncogenes and alterations of cellular metabolism. Furthermore, several clinical trials have shown that metabolic imaging can significantly impact patient management by improving tumor staging, restaging, radiation treatment planning, and monitoring of tumor response to therapy. In this review, we summarize recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism.

引用

页码：43S / 63S

页数：21

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