Synthesis of N-(2-chloroethyl)glycine and -DL-alanine esters

被引：1
|
作者：
Aladzheva, I. M. [1 ]
Bykhovskaya, O. V. [1 ]
Petrovskii, P. V. [1 ]
Mastryukova, T. A. [1 ]
机构：
[1] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2007年 / 56卷 / 12期
基金：
俄罗斯基础研究基金会;
关键词：
N-(2-chloroethyl)glycine; N-(2-chloroethyl)-DL-alanine; amino acids; reductive amination; alkylation; two-phase systems;
D O I：
10.1007/s11172-007-0390-8
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two methods for the synthesis of N-(2-chloroethyl)glycine and -DL-alanine esters are proposed: 1) reductive amination of the C=O group of glyoxilic or pyruvic acids upon treatment with 2-chloroethylamine and sodium cyanoborohydride in methanol and 2) alkylation of 2-chloroethylamine with cc-haloalkanoic acid esters in K2CO3-MeCN two-phase system.
引用
收藏
页码：2456 / 2459
页数：4
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