Synthesis, anticancer and molecular docking studies of benzofuran derivatives

被引：10

作者：

Swamy, Purawarga Mathada Gurubasavaraja ^{[1
]}

Prasad, Yejalla Rajendra ^{[2
]}

Ashvini, Hire Mathada ^{[1
]}

Giles, D. ^{[1
]}

Shashidhar, Byrappa Venkataraju ^{[1
]}

Agasimundin, Y. S. ^{[3
]}

机构：

[1] Acharya & BM Reddy Coll Pharm, Med Chem Res Lab, Bangalore 560107, Karnataka, India

[2] Univ Coll Pharmaceut Sci, Med Chem Res Lab, Visakapatnam 530003, Andhra Pradesh, India

[3] SCS Coll Pharm, Med Chem Res Lab, Harapanahalli 583131, Karnataka, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 09期

关键词：

Amino pyrimidines; Azetidinones; Anticancer activity; Docking study; INHIBITORS; CANCER; POTENT;

D O I：

10.1007/s00044-015-1391-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel benzofuran scaffolds of amino pyrimidines (5a-5s) and azetidinones (17a-17j) were synthesized as potent bi-heterocyclic molecules. All the newly synthesized compounds were confirmed by spectral studies. These synthesized compounds were screened for in vivo anticancer activity. Compounds 5s, 5r and 17b displayed the highest anticancer activity against Ehrlich ascites carcinoma cells, and docking study of all the synthesized title compounds was carried out using Molegro Virtual Docker on GABA receptor-associated protein-like 1 cancer receptor. These studies revealed the importance of benzofuran, amino pyrimidines and azetidinone nucleus for their anticancer activity.

引用

页码：3437 / 3452

页数：16

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