Targeting fibroblast-like synoviocytes in rheumatoid arthritis

被引：88

作者：

Tsaltskan, Vladislav ^{[1
]}

Firestein, Gary S. ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Div Rheumatol, Allergy & Immunol, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2022年 / 67卷

关键词：

FACTOR-KAPPA-B; RECEPTOR ACTIVATOR; SYNOVIAL-CELLS; GENE-EXPRESSION; TNF-ALPHA; LEFLUNOMIDE; METHOTREXATE; INHIBITORS; IL-6; HYDROXYCHLOROQUINE;

D O I：

10.1016/j.coph.2022.102304

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Fibroblast-like synoviocytes (FLS) are mesenchymal-derived cells that play an important role in the physiology of the synovium by producing certain components of the synovial fluid and articular cartilage. In rheumatoid arthritis (RA), however, fibroblasts become a key driver of synovial inflammation and joint damage. Because of this, there has been recent interest in FLS as a therapeutic target in RA to avoid side effects such as systemic immune suppression associated with many existing RA treatments. In this review, we describe how approved treatments for RA affect FLS signaling and function and discuss the effects of investigational FLS-targeted drugs for RA.

引用

页数：8

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