Immune responses after live attenuated influenza vaccination

被引：118
作者：
Mohn, Kristin G. -I. [1 ,2 ]
Smith, Ingrid [3 ]
Sjursen, Haakon [4 ]
Cox, Rebecca Jane [1 ,3 ,5 ]
机构：
[1] Haukeland Hosp, Influenza Ctr, Bergen, Norway
[2] Haukeland Hosp, Emergency Care Clin, Bergen, Norway
[3] Haukeland Hosp, Dept Res & Dev, Bergen, Norway
[4] Haukeland Hosp, Dept Med, Bergen, Norway
[5] Univ Bergen, Dept Clin Sci, Jebsen Ctr Influenza Vaccines, Bergen, Norway
来源：
HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2018年 / 14卷 / 03期
关键词：
Antibody; immune response; live attenuated influenza vaccine (LAIV); T-cell; CULTURE-CONFIRMED INFLUENZA; B-CELL RESPONSES; ANN-ARBOR STRAIN; CD8(+) T-CELLS; SEASONAL INFLUENZA; YOUNG-CHILDREN; VIRUS VACCINE; NEURAMINIDASE INHIBITORS; RELATIVE EFFICACY; DOUBLE-BLIND;
D O I：
10.1080/21645515.2017.1377376
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Since 2003 (US) and 2012 (Europe) the live attenuated influenza vaccine (LAIV) has been used as an alternative to the traditional inactivated influenza vaccines (IIV). The immune responses elicted by LAIV mimic natural infection and have been found to provide broader clinical protection in children compared to the IIVs. However, our knowledge of the detailed immunological mechanisims induced by LAIV remain to be fully elucidated, and despite 14years on the global market, there exists no correlate of protection. Recently, matters are further complicated by differing efficacy data from the US and Europe which are not understood. Better understanding of the immune responses after LAIV may aid in achieving the ultimate goal of a future universal influenza vaccine. In this review we aim to cover the current understanding of the immune responses induced after LAIV.
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收藏
页码：571 / 578
页数：8
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