FGF23 and PTH-double agents at the heart of CKD

被引:51
作者
Silver, Justin [1 ]
Rodriguez, Mariano [2 ]
Slatopolsky, Eduardo [3 ]
机构
[1] Hadassah Hebrew Univ, Med Ctr, Dept Nephrol, Jerusalem, Israel
[2] Hosp Univ Reina Sofia IMIBIC, Serv Nephrol, Cordoba, Spain
[3] Washington Univ, Sch Med, Div Renal, St Louis, MO 63110 USA
关键词
FGF23; left ventricular hypertrophy; mineral metabolism; phosphorus; PTH; GROWTH-FACTOR; 23; RENAL PHOSPHATE-TRANSPORT; CHRONIC KIDNEY-DISEASE; VITAMIN-D; SECONDARY HYPERPARATHYROIDISM; PARATHYROID-HORMONE; GENE-EXPRESSION; HEMODIALYSIS-PATIENTS; PROXIMAL TUBULE; KLOTHO;
D O I
10.1093/ndt/gfs050
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
[No abstract available]
引用
收藏
页码:1715 / 1720
页数:6
相关论文
共 58 条
[31]   Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone [J].
Liu, Shiguang ;
Tang, Wen ;
Fang, Jianwen ;
Ren, Jinyu ;
Li, Hua ;
Xiao, Zhousheng ;
Quarles, L. D. .
MOLECULAR ENDOCRINOLOGY, 2009, 23 (09) :1505-1518
[32]   Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo [J].
Lopez, Ignacio ;
Encarnacion Rodriguez-Ortiz, M. ;
Almaden, Yolanda ;
Guerrero, Fatima ;
Montes de Oca, A. ;
Pineda, Carmen ;
Shalhoub, Vicky ;
Rodriguez, Mariano ;
Aguilera-Tejero, Escolastico .
KIDNEY INTERNATIONAL, 2011, 80 (05) :475-482
[33]   PHOSPHORUS RESTRICTION REVERSES HYPERPARATHYROIDISM IN UREMIA INDEPENDENT OF CHANGES IN CALCIUM AND CALCITRIOL [J].
LOPEZHILKER, S ;
DUSSO, AS ;
RAPP, NS ;
MARTIN, KJ ;
SLATOPOLSKY, E .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (03) :F432-F437
[34]   Role of microtubules in the rapid regulation of renal phosphate transport in response to acute alterations in dietary phosphate content [J].
Lotscher, M ;
Kaissling, B ;
Biber, J ;
Murer, H ;
Levi, M ;
Wilson, P ;
Nguyen, S .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (06) :1302-1312
[35]   Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling [J].
Martin, Aline ;
Liu, Shiguang ;
David, Valentin ;
Li, Hua ;
Karydis, Anastasios ;
Feng, Jian Q. ;
Quarles, L. Darryl .
FASEB JOURNAL, 2011, 25 (08) :2551-2562
[36]  
Massry S G, 1987, Adv Exp Med Biol, V223, P1
[37]   Calcineurin Aβ is central to the expression of the renal type IINa/Pi co-transporter gene and to the regulation of renal phosphate transport [J].
Moz, Y ;
Levi, R ;
Lavi-Moshayoff, V ;
Cox, KB ;
Molkentin, JD ;
Silver, J ;
Naveh-Many, T .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (12) :2972-2980
[38]   Characterization of cis-acting element in renal NaPi-2 cotransporter mRNA that determines mRNA stability [J].
Moz, Y ;
Silver, J ;
Naveh-Many, T .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 284 (04) :F663-F670
[39]   Regulation of Na/Pi transporter in the proximal tubule [J].
Murer, H ;
Hernando, N ;
Forster, I ;
Biber, J .
ANNUAL REVIEW OF PHYSIOLOGY, 2003, 65 :531-542
[40]   PARATHYROID CELL-PROLIFERATION IN NORMAL AND CHRONIC-RENAL-FAILURE RATS - THE EFFECTS OF CALCIUM, PHOSPHATE, AND VITAMIN-D [J].
NAVEHMANY, T ;
RAHAMIMOV, R ;
LIVNI, N ;
SILVER, J .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (04) :1786-1793