Bioactive Lipids and Redox Signaling: Molecular Mechanism and Disease Pathogenesis

被引:23
作者
Li, Pin-Lan [1 ]
Gulbins, Erich [2 ]
机构
[1] Virginia Commonwealth Univ, Sch Med, Dept Pharmacol & Toxicol, Med Coll Virginia Campus,410 North 12th St, Richmond, VA 23298 USA
[2] Univ Duisburg Essen, Inst Mol Biol, Essen, Germany
基金
美国国家卫生研究院;
关键词
lipid mediators; ROS; ceramide; sphingolipids; lysophospholipids; eicosanoids;
D O I
10.1089/ars.2017.7467
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The actions of bioactive lipids and reactive oxygen species (ROS) are usually coupled, and their interplay is a common and important mechanism mediating tissue injury, inflammation, and other pathologies. Understanding the interplay of ROS and lipid mediators will extend horizons for researchers to clarify the pathogenesis of different diseases and help identify therapeutic targets for treatment of these diseases. Some bioactive lipids are converted into oxidized lipids during cell or tissue oxidative stress such as isoprostanes and isoketals, which are even more bioactive than their precursors. Moreover, many enzymes that produce lipid mediators such as prostaglandin H synthases, lipoxygenases, and cytochrome P450 isoforms may catalyze the production of ROS. Bioactive lipids-lysophospholipids, sphingolipids, or deposited lipids in cellsare shown to stimulate redox enzymes to produce ROS. In addition, a lipid-channel-ROS axis in different organelles may be associated with the crosstalk of ROS and bioactive lipids. This Forum focuses on the crosstalk of ROS with sphingolipids, P450 eicosanoids, lysophospholipids, and deposited plasma lipids and related novel signaling pathway in their reciprocal actions, which is expected to provide novel insights into the pathogenesis of different diseases associated with the participation of these lipid mediators. It is imperative to further understand the molecular mechanism mediating the crosstalk of ROS with specific lipid mediators and to develop more effective therapeutic strategies to target the interplay of ROS and lipid mediators for treatment specific to different organ diseases. Antioxid. Redox Signal. 00, 000-000.
引用
收藏
页码:911 / 915
页数:5
相关论文
共 31 条
  • [21] The molecular mechanism of ferroptosis and its relationship with Parkinson's disease
    Su, Yan
    Jiao, Yue
    Cai, Sheng
    Xu, Yang
    Wang, Qi
    Chen, Xianwen
    BRAIN RESEARCH BULLETIN, 2024, 213
  • [22] Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease
    Ceren Emre
    Khanh V. Do
    Bokkyoo Jun
    Erik Hjorth
    Silvia Gómez Alcalde
    Marie-Audrey I. Kautzmann
    William C. Gordon
    Per Nilsson
    Nicolas G. Bazan
    Marianne Schultzberg
    Acta Neuropathologica Communications, 9
  • [23] Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease
    Emre, Ceren
    Do, Khanh, V
    Jun, Bokkyoo
    Hjorth, Erik
    Alcalde, Silvia Gomez
    Kautzmann, Marie-Audrey, I
    Gordon, William C.
    Nilsson, Per
    Bazan, Nicolas G.
    Schultzberg, Marianne
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2021, 9 (01)
  • [24] Modulation of oxidative stress and apoptosis by alteration of bioactive lipids in the pancreas, and effect of zinc chelation in a rat model of Alzheimer's disease
    Acun, Alev Duygu
    Kantar, Deniz
    JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2024, 85
  • [25] Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress
    Wang, Jie
    Pareja, Kristeen A.
    Kaiser, Chris A.
    Sevier, Carolyn S.
    ELIFE, 2014, 3 : e03496
  • [26] Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic Interventions
    Rahman, Md. Ataur
    Ahmed, Kazi Rejvee
    Haque, Farzana
    Park, Moon Nyeo
    Kim, Bonglee
    ANTIOXIDANTS, 2023, 12 (02)
  • [27] Oxidative stress, a common molecular pathway for kidney disease: Role of the redox enzyme p66Shc
    Yang, Shi-Kun
    Xiao, Li
    Li, Jun
    Liu, Fuyou
    Sun, Lin
    RENAL FAILURE, 2014, 36 (02) : 313 - 320
  • [28] Cognitive Decline, Dementia, Alzheimer's Disease and Presbycusis: Examination of the Possible Molecular Mechanism
    Shen, Yilin
    Ye, Bin
    Chen, Penghui
    Wang, Quan
    Fan, Cui
    Shu, Yilai
    Xiang, Mingliang
    FRONTIERS IN NEUROSCIENCE, 2018, 12
  • [29] Exploring the mechanism of metformin action in Alzheimer's disease and type 2 diabetes based on network pharmacology, molecular docking, and molecular dynamic simulation
    Shi, Xin
    Li, Lingling
    Liu, Zhiyao
    Wang, Fangqi
    Huang, Hailiang
    THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM, 2023, 14
  • [30] The key role of sphingosine kinases in the molecular mechanism of neuronal cell survival and death in an experimental model of Parkinson's disease
    Pyszko, Joanna A.
    Strosznajder, Joanna B.
    FOLIA NEUROPATHOLOGICA, 2014, 52 (03) : 260 - 269