Monoamine transporter and enzyme expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss

被引：43

作者：

Goddard, Matthew ^{[1
]}

Zheng, Yiwen ^{[1
]}

Darlington, Cynthia L. ^{[1
]}

Smith, Paul F. ^{[1
]}

机构：

[1] Univ Otago, Sch Med Sci, Dept Pharmacol & Toxicol, Dunedin, New Zealand

来源：

NEUROSCIENCE LETTERS | 2008年 / 437卷 / 02期

关键词：

bilateral vestibular deafferentation; medical temporal lobe; serotonin transporter; dopamine transporter; tyrosine hydroxylase; tryptophan hydroxylase; dopamine hydroxylase;

D O I：

10.1016/j.neulet.2008.03.073

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Peripheral vestibular damage has been reported to be associated with a high incidence of anxiety disorders and depression. In this study we investigated whether chronic bilateral vestibular deafferentation (BVD) would affect the expression of several biogenic amine enzymes and transporters in the medial temporal lobe (CA1, CA2/3, dentate gyrus (DG), entorhinal (EC) and perirhinal cortices (PRC)) and frontal lobes (FL) of rats. BVD was not associated with any significant differences in dopamine beta-hydroxylase or the dopamine transporter in any brain region studied. There was a significant decrease in tyrosine hydroxylase expression only in the FL and a significant decrease in the expression of the serotonin transporter in the FL and CA1 in BVD Fats. Tryptophan hydroxlase showed a significant increase in expression in the FL, CA2/3, and DG and a significant decrease in the EC. These results suggest that biogenic amine pathways in the medial temporal lobe and FL undergo changes following BVD. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：107 / 110

页数：4

共 30 条

[1]

[Anonymous], 2000, NEUROPSYCHOLOGY ANXI

[2]

BAHRING R, 1994, EXP BRAIN RES, V98, P391

[3] Neural substrates linking balance control and anxiety [J].

Balaban, CD .

PHYSIOLOGY & BEHAVIOR, 2002, 77 (4-5) :469-475

[4] Neurological bases for balance-anxiety links [J].

Balaban, CD ;

Thayer, JF .

JOURNAL OF ANXIETY DISORDERS, 2001, 15 (1-2) :53-79

[5]

BIRGERSON L, 1994, OTOLARYNGOL, V114, P529

[6] Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans [J].

Brandt, T ;

Schautzer, F ;

Hamilton, DA ;

Brüning, R ;

Markowitsch, HJ ;

Kalla, R ;

Darlington, C ;

Smith, P ;

Strupp, M .

BRAIN, 2005, 128 :2732-2741

[7] Opinion -: Is mood chemistry? [J].

Castrén, E .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (03) :241-246

[8]

Cransac H, 1996, J VESTIBUL RES-EQUIL, V6, P243

[9]

D'Ascanio P, 1998, ARCH ITAL BIOL, V136, P83

[10]

D'Ascanio P, 2000, ARCH ITAL BIOL, V138, P241

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