Disease-associated astrocytes in Alzheimer's disease and aging

被引：552

作者：

Habib, Naomi ^{[1
,2
]}

McCabe, Cristin ^{[2
]}

Medina, Sedi ^{[3
]}

Varshavsky, Miriam ^{[1
]}

Kitsberg, Daniel ^{[1
]}

Dvir-Szternfeld, Raz ^{[3
]}

Green, Gilad ^{[1
]}

Dionne, Danielle ^{[2
]}

Nguyen, Lan ^{[2
]}

Marshall, Jamie L. ^{[2
]}

Chen, Fei ^{[2
]}

Zhang, Feng ^{[2
,4
,5
]}

Kaplan, Tommy ^{[6
]}

Regev, Aviv ^{[2
,7
]}

Schwartz, Michal ^{[2
,3
]}

机构：

[1] Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, Jerusalem, Israel

[2] Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA

[3] Weizmann Inst Sci, Dept Neurobiol, Rehovot, Israel

[4] MIT, Howard Hughes Med Inst, McGovern Inst Brain Res, Dept Brain & Cognit Sci, Cambridge, MA USA

[5] MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[6] Hebrew Univ Jerusalem, Sch Comp Sci & Engn, Jerusalem, Israel

[7] MIT, Howard Hughes Med Inst, Koch Inst Integrat Canc Res, Dept Biol, Cambridge, MA USA

来源：

NATURE NEUROSCIENCE | 2020年 / 23卷 / 06期

基金：

欧洲研究理事会; 以色列科学基金会;

关键词：

NUCLEUS RNA-SEQ; EXPRESSION; PATHOLOGY; BETA;

D O I：

10.1038/s41593-020-0624-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of non-neuronal cells in Alzheimer's disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer's disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors. A new subset of disease-associated astrocytes (DAAs) is identified in a mouse model of Alzheimer's disease by single-nucleus RNA sequencing. DAAs are also found in aged wild-type mice, suggesting a link to genetic and age-related factors.

引用

页码：701 / +

页数：25

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