A Reported "New Synthesis of Lysergic Acid" Yields Only The Derailment Product: Methyl 5-Methoxy-4,5-dihydroindolo[4,3-f,g]quinoline-9-carboxylate

被引：15

作者：

Bekkam, Markondaiah ^{[1
]}

Mo, Huaping ^{[1
]}

Nichols, David E. ^{[1
]}

机构：

[1] Purdue Univ, Coll Pharm, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 01期

关键词：

LSD-LIKE ACTIVITY; SERIES; POTENT; AMIDES;

D O I：

10.1021/ol203048q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The treatment of ethyl 6-formy1-5-(1H-Indol-411)pyridine-3-carboxylate (2) with NaOMe or NaOH in methanol solution at room temperature under the reported reaction conditions afforded solely product 4 in 80% yield, rather than anticipated product 3.

引用

页码：296 / 298

页数：3

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