Involvement of group I mGluRs in UP induced by strong high frequency stimulation in the dentate gyrus in vitro

被引：17

作者：

Wu, Jianqun ^{[1
]}

Harney, Sarah ^{[1
]}

Rowan, Michael J.

Anwyl, Roger ^{[1
]}

机构：

[1] Trinity Coll Dublin, Dept Physiol, Dublin 2, Ireland

来源：

NEUROSCIENCE LETTERS | 2008年 / 436卷 / 02期

基金：

爱尔兰科学基金会;

关键词：

LTP; mGluR5; ryanodine; dentate gyros;

D O I：

10.1016/j.neulet.2008.03.027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The involvement of group I metabotropic glutamate receptors (mGluRs) and ryanodine receptors was investigated in the induction of LTP induced either by application of one standard high frequency stimulation (HFS) or by strong multiple HFS in the medial perforant path to granule cell synapse of the rat dentate gyrus. Whilst a standard brief HFS induced LTP close to 50%, strong stimulation consisting of multiple HFS induced a much larger LTP. mGIuR5 was found to be partially involved in the induction of the enhanced LTP induced by the strong HFS but not in the standard LTP induced by the brief HFS. Thus the mGIuR5 antagonists LY341495 and MPEP partially inhibited the induction of LTP induced by strong HFS but did not inhibit LTP induced by a standard HFS. Ryanodine was found to partially inhibit LTP induced by the strong HFS but not to inhibit the standard LTP induced by the brief HFS, demonstrating the involvement of Ca-induced Ca release from ryanodine-sensitive Ca stores in the former. These studies demonstrate that the large amplitude LTP induced by strong stimulation involves additional mechanisms to the LTP induced by brief HFS, in particular involving activation of mGIuR5 and RyR-sensitive Ca stores. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：235 / 238

页数：4

共 19 条

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