Boosting resolution in NMR spectroscopy by chemical shift upscaling

被引：4

作者：

Zeng, Qing ^{[1
]}

Chen, Jinyong ^{[1
]}

Lin, Yanqin ^{[1
]}

Chen, Zhong ^{[1
]}

机构：

[1] Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

来源：

ANALYTICA CHIMICA ACTA | 2020年 / 1110卷

基金：

中国国家自然科学基金;

关键词：

Nuclear magnetic resonance (NMR); Chemical shift; Scalar coupling; Spectral resolution; Quantification; MAGNETIC-FIELD HOMOGENEITY; IN-PHASE; SPECTRA; COSY;

D O I：

10.1016/j.aca.2020.03.032

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Resolution is an essential challenge in NMR spectroscopy. Narrow chemical shift range and extensive signal splittings due to scalar couplings often give rise to spectral congestion and even overlap in NMR spectra. Magnetic field strength is directly responsible for spectral resolution as higher magnetic field strength offers better signal dispersion. However, the process of further increasing magnetic field strength of NMR instruments is slow and expensive. Methodology aimed at resolution issue has long been developing. Here, we present a chemical shift upscaling method, in which chemical shifts are upscaled by a given factor while scalar couplings are unchanged. As a result, signal dispersion and hence the resolution are improved. Therefore, it is possible to separate multiplets which originally overlap with each other and to extract their integrals for quantitative analysis. Improved signal dispersion and the preservation of scalar couplings also facilitate multiplet analysis and signal assignment. Chemical shift upscaling offers a method for enhancing resolution limited by magnetic field strength.(C) 2020 Elsevier B.V. All rights reserved.

引用

页码：109 / 114

页数：6

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