Hyaluronic Acid-Based Theranostic Nanomedicines for Targeted Cancer Therapy

被引：114
作者：
Lee, So Yun [1 ]
Kang, Moon Sung [2 ]
Jeong, Woo Yeup [1 ]
Han, Dong-Wook [2 ]
Kim, Ki Su [1 ]
机构：
[1] Pusan Natl Univ, Coll Engn, Dept Organ Mat Sci & Engn, 2 Busandaehak Ro 63 Beon Gil, Busan 46241, South Korea
[2] Pusan Natl Univ, Coll Nanosci & Nanotechnol, Dept Cognomechat Engn, 2 Busandaehak Ro 63 Beon Gil, Busan 46241, South Korea
来源：
CANCERS | 2020年 / 12卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
hyaluronic acid; cancer therapy; anticancer agent; theranosis; nanomedicine; receptors; TYRAMINE HYDROGEL SYSTEM; REDUCED GRAPHENE OXIDE; ANTICANCER DRUG; GOLD NANOPARTICLES; MULTIFUNCTIONAL NANOPARTICLES; INTRACELLULAR DELIVERY; LUNG-CANCER; CD44; DOXORUBICIN; MICELLES;
D O I：
10.3390/cancers12040940
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hyaluronic acid (HA) is a natural mucopolysaccharide and has many useful advantages, including biocompatibility, non-immunogenicity, chemical versatility, non-toxicity, biodegradability, and high hydrophilicity. Numerous tumor cells overexpress several receptors that have a high binding affinity for HA, while these receptors are poorly expressed in normal body cells. HA-based drug delivery carriers can offer improved solubility and stability of anticancer drugs in biological environments and allow for the targeting of cancer treatments. Based on these benefits, HA has been widely investigated as a promising material for developing the advanced clinical cancer therapies in various formulations, including nanoparticles, micelles, liposomes, and hydrogels, combined with other materials. We describe various approaches and findings showing the feasibility of improvement in theragnosis probes through the application of HA.
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页数：17
相关论文
共 109 条
[51]   Hyaluronic Acid-Gold Nanoparticle/Interferon α Complex for Targeted Treatment of Hepatitis C Virus Infection [J].
Lee, Min-Young ;
Yang, Jeong-A ;
Jung, Ho Sang ;
Beack, Songeun ;
Choi, Jung Eun ;
Hur, Wonhee ;
Koo, Heebeom ;
Kim, Kwangmeyung ;
Yoon, Seung Kew ;
Hahn, Sei Kwang .
ACS NANO, 2012, 6 (11) :9522-9531
[52]   Thermo-sensitive, injectable, and tissue adhesive sol-gel transition hyaluronic acid/pluronic composite hydrogels prepared from bio-inspired catechol-thiol reaction [J].
Lee, Yuhan ;
Chung, Hyun Jung ;
Yeo, Sangho ;
Ahn, Cheol-Hee ;
Lee, Haeshin ;
Messersmith, Phillip B. ;
Park, Tae Gwan .
SOFT MATTER, 2010, 6 (05) :977-983
[53]   Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel [J].
Li, Jing ;
Huo, Meirong ;
Wang, Jing ;
Zhou, Jianping ;
Mohammad, Jumah M. ;
Zhang, Yinlong ;
Zhu, Qinnv ;
Waddad, Ayman Y. ;
Zhang, Qiang .
BIOMATERIALS, 2012, 33 (07) :2310-2320
[54]   Hyaluronic acid-modified hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging [J].
Li, Jingchao ;
He, Yao ;
Sun, Wenjie ;
Luo, Yu ;
Cai, Hongdong ;
Pan, Yunqi ;
Shen, Mingwu ;
Xia, Jindong ;
Shi, Xiangyang .
BIOMATERIALS, 2014, 35 (11) :3666-3677
[55]   Hyaluronic acid functionalized green reduced graphene oxide for targeted cancer photothermal therapy [J].
Lima-Sousa, Rita ;
de Melo-Diogo, Duarte ;
Alves, Catia G. ;
Costa, Elisabete C. ;
Ferreira, Paula ;
Louro, Ricardo O. ;
Correia, Ilidio J. .
CARBOHYDRATE POLYMERS, 2018, 200 :93-99
[56]   Thiol-Mediated Synthesis of Hyaluronic Acid-Epigallocatechin-3-O-Gallate Conjugates for the Formation of Injectable Hydrogels with Free Radical Scavenging Property and Degradation Resistance [J].
Liu, Chixuan ;
Bae, Ki Hyun ;
Yamashita, Atsushi ;
Chung, Joo Eun ;
Kurisawa, Motoichi .
BIOMACROMOLECULES, 2017, 18 (10) :3143-3155
[57]   Mixed micelle systems formed from critical micelle concentration and temperature-sensitive diblock copolymers for doxorubicin delivery [J].
Lo, Chun-Liang ;
Lin, Sheng-Jie ;
Tsai, Hsieh-Chih ;
Chan, Wei-Hsiang ;
Tsai, Cheng-Hung ;
Cheng, Chien-Hsin D. ;
Hsiue, Ging-Ho .
BIOMATERIALS, 2009, 30 (23-24) :3961-3970
[58]   Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine [J].
Mattheolabakis, George ;
Milane, Lara ;
Singh, Amit ;
Amiji, Mansoor M. .
JOURNAL OF DRUG TARGETING, 2015, 23 (7-8) :605-618
[59]  
Mattheolabakis G, 2012, NANOMEDICINE-UK, V7, P1577, DOI [10.2217/NNM.12.128, 10.2217/nnm.12.128]
[60]   Cholesteryl hyaluronic acid-coated, reduced graphene oxide nanosheets for anti-cancer drug delivery [J].
Miao, Wenjun ;
Shim, Gayong ;
Kang, Choong Mo ;
Lee, Soondong ;
Choe, Yearn Seong ;
Choi, Han-Gon ;
Oh, Yu-Kyoung .
BIOMATERIALS, 2013, 34 (37) :9638-9647
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