Luxotonic signals in human prefrontal cortex as a possible substrate for effects of light on mood and cognition

被引：18

作者：

Sabbah, Shai ^{[1
]}

Worden, Michael S. ^{[2
,3
]}

Laniado, Dimitrios D. ^{[1
]}

Berson, David M. ^{[2
,3
]}

Sanes, Jerome N. ^{[2
,3
,4
]}

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Dept Med Neurobiol, IL-9112102 Jerusalem, Israel

[2] Brown Univ, Dept Neurosci, Providence, RI 02912 USA

[3] Brown Univ, Carney Inst Brain Sci, Providence, RI 02912 USA

[4] Vet Affairs Providence Healthcare Syst, Ctr Neurorestorat & Neurotechnol, Providence, RI 02908 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2022年 / 119卷 / 28期

关键词：

light-sensitive brain regions; fMRI; humans; frontal lobe; RETINAL GANGLION-CELLS; HUMAN VISUAL-CORTEX; WORKING-MEMORY; FUNCTIONAL NEUROANATOMY; MELATONIN SECRETION; INTRAPARIETAL AREA; CINGULATE CORTEX; EXPOSURE; ACTIVATION; DEPRESSION;

D O I：

10.1073/pnas.2118192119

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Studies with experimental animals have revealed a mood-regulating neural pathway linking intrinsically photosensitive retinal ganglion cells (ipRGCs) and the prefrontal cortex (PFC), involved in the pathophysiology of mood disorders. Since humans also have light-intensity-encoding ipRGCs, we asked whether a similar pathway exists in humans. Here, functional MRI was used to identify PFC regions and other areas exhibiting light-intensity-dependent signals. We report 26 human brain regions having activation that either monotonically decreases or monotonically increases with light intensity. Luxotonic-related activation occurred across the cerebral cortex, in diverse subcortical structures, and in the cerebellum, encompassing regions with functions related to visual image formation, motor control, cognition, and emotion. Light suppressed PFC activation, which monotonically decreased with increasing light intensity. The sustained time course of light-evoked PFC responses and their susceptibility to prior light exposure resembled those of ipRGCs. These findings offer a functional link between light exposure and PFC-mediated cognitive and affective phenomena.

引用

页数：10

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