MicroRNAs: Small molecules with big roles in neurodevelopment and diseases

被引：135

作者：

Sun, Emily ^{[1
]}

Shi, Yanhong ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, Beckman Res Inst, Dept Neurosci, Ctr Canc, Duarte, CA 91010 USA

来源：

EXPERIMENTAL NEUROLOGY | 2015年 / 268卷

关键词：

miRNA; Neurodevelopment; Neural stem cells; Neuronal differentiation and maturation; Schizophrenia; Bipolar disorder; NEURAL STEM-CELL; NUCLEAR RECEPTOR TLX; HUMAN NEURONAL DIFFERENTIATION; BRAIN-EXPRESSED MICRORNAS; NEGATIVE FEEDBACK LOOP; BIPOLAR DISORDER; PREFRONTAL CORTEX; SUBVENTRICULAR ZONE; MESSENGER-RNA; OLIGODENDROCYTE DIFFERENTIATION;

D O I：

10.1016/j.expneurol.2014.08.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that play important roles in the development and functions of the brain. Extensive studies have revealed critical roles for miRNAs in brain development and function. Dysregulation or altered expression of miRNAs is associated with abnormal brain development and pathogenesis of neurodevelopmental diseases. This review serves to highlight the versatile roles of these small RNA molecules in normal brain development and their association with neurodevelopmental disorders, in particular, two closely related neuropsychiatric disorders of neurodevelopmental origin, schizophrenia and bipolar disorder. (C) 2014 The Authors. Published by Elsevier Inc.

引用

页码：46 / 53

页数：8

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