Two Co(II) Coordination Polymers: Crystal Structures and Treatment Activity on Brain Injury Combined with Ratanasampil (RNSP)

被引：0

作者：

Ma, Hui ^{[1
,2
]}

Rong, Hao ^{[1
,2
]}

Zheng, Qi-Sun ^{[1
,2
]}

Shi, Jing-Ming ^{[1
,2
]}

机构：

[1] Xizang Minzu Univ, Sch Med, Xianyang 712082, Peoples R China

[2] Xizang Minzu Univ, Sch Med, Key Lab High Altitude Environm & Genes Related Dis, Xianyang 712082, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2022年 / 41卷 / 09期

关键词：

Coordination polymers; brain injury; RNSP;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two new Co(II)-containing coordination polymers, as known as {[Co(L)(H2O)(2)]center dot 2H(2)O}n (1) and {[Co(L)(H2O)(2)]center dot 1.5 H2O}(n )(2) have been obtained by reaction of the metal salt Co(NO3)(2)center dot 6H(2)O with the T-shaped ligand (4-3'-pyridyl-,6-4'-carboxylphenyl)picolinic acid (H2L) in the solvothermal reaction environments. Their therapeutic modalities against the local brain injury combined with rnsp were evaluated. First of all, the content of the inflammatory cytokines released into the cerebrospinal fluid after the added compound combined with RNSP was detected with ELISA assay. Moreover, the activity of JAK/STAT3 signaling pathway was evaluated by real time RT-PCR.

引用

页码：1787 / 1792

页数：6

共 18 条

[1] Five transition metal coordination polymers driven by a semirigid trifunctional nicotinic acid ligand: selective adsorption and magnetic properties [J].

Bai, Nannan ;

Gao, Ruicheng ;

Wang, Haihua ;

Wu, Yunlong ;

Hou, Lei ;

Wang, Yao-Yu .

CRYSTENGCOMM, 2018, 20 (38) :5726-5734

[2] Enhancing Metal-Organic Framework Net Robustness by Successive Linker Coordination Increase: From a Hydrogen-Bonded Two-Dimensional Supramolecular Net to a Covalent One Keeping the Topology [J].

D'Vries, Richard F. ;

de la Pena-O'Shea, Victor A. ;

Benito Hernandez, Angela ;

Snejko, Natalia ;

Gutierrez-Puebla, Enrique ;

Angeles Monge, M. .

CRYSTAL GROWTH & DESIGN, 2014, 14 (10) :5227-5233

[3] Traumatic Brain Injury: Current Treatment Strategies and Future Endeavors [J].

Galgano, Michael ;

Toshkezi, Gentian ;

Qiu, Xuecheng ;

Russell, Thomas ;

Chin, Lawrence ;

Zhao, Li-Ru .

CELL TRANSPLANTATION, 2017, 26 (07) :1118-1130

[4] A new type of pH-responsive coordination polymer sphere as a vehicle for targeted anticancer drug delivery and sustained release [J].

Gao, Peng Fei ;

Zheng, Lin Ling ;

Liang, Li Jiao ;

Yang, Xiao Xi ;

Li, Yuan Fang ;

Huang, Cheng Zhi .

JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (25) :3202-3208

[5] Recent advances in traumatic brain injury [J].

Khellaf, Abdelhakim ;

Khan, Danyal Zaman ;

Helmy, Adel .

JOURNAL OF NEUROLOGY, 2019, 266 (11) :2878-2889

[6] A highly selective multifunctional Zn-coordination polymer sensor for detection of Cr (III), Cr (VI) ion, and TNP molecule [J].

Liang, Xiaoyu ;

Jia, Yuejiao ;

Zhan, Zhiying ;

Hu, Ming .

APPLIED ORGANOMETALLIC CHEMISTRY, 2019, 33 (08)

[7] Anion-Controlled Architecture and Photochromism of Naphthalene Diimide-Based Coordination Polymers [J].

Liu, Jian-Jun ;

Xia, Shu-Biao ;

Duan, Yu-Lian ;

Liu, Teng ;

Cheng, Fei-Xiang ;

Sun, Cheng-Ke .

POLYMERS, 2018, 10 (02)

[8] Green Approach To Synthesize Crystalline Nanoscale ZnII-Coordination Polymers: Cell Growth Inhibition and Immunofluorescence Study [J].

Mukherjee, Somali ;

Ganguly, Sumi ;

Manna, Krishnendu ;

Mondal, Sanchaita ;

Mahapatra, Supratim ;

Das, Debasis .

INORGANIC CHEMISTRY, 2018, 57 (07) :4050-4060

[9] A novel water soluble ligand bridged cobalt(II) coordination polymer of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (isonicotinic) hydrazone: evaluation of the DNA binding, protein interaction, radical scavenging and anticancer activity [J].

Raja, Duraisamy Senthil ;

Bhuvanesh, Nattamai S. P. ;

Natarajan, Karuppannan .

DALTON TRANSACTIONS, 2012, 41 (15) :4365-4377

[10] Exploiting dimensional variability in coordination polymers: solvent promotes reversible conversion between 3D and chiral 1D architectures [J].

Rancan, Marzio ;

Armelao, Lidia .

CHEMICAL COMMUNICATIONS, 2015, 51 (65) :12947-12949

← 1 2 →