Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases

被引：82

作者：

Gardoni, Fabrizio ^{[1
]}

Bellone, Camilla ^{[2
]}

机构：

[1] Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy

[2] Univ Lausanne, Dept Fundamental Neurosci, CH-1005 Lausanne, Switzerland

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2015年 / 9卷

关键词：

Dopamine; NMDA receptor; AMPA receptors; Addiction; Parkinson disease; Huntington disease; LONG-TERM POTENTIATION; EVOKED SYNAPTIC PLASTICITY; RECEPTOR-MEDIATED EXCITOTOXICITY; STRIATAL PROJECTION NEURONS; TRANSGENIC MOUSE MODEL; GLUR1 AMPA RECEPTOR; NMDA RECEPTOR; PREFRONTAL CORTEX; D-2; RECEPTOR; D1;

D O I：

10.3389/fncel.2015.00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dopamine (DA) plays a major role in motor and cognitive functions as well as in reward processing by regulating glutamatergic inputs. In particular in the striatum the release of DA rapidly influences synaptic transmission modulating both AMPA and NMDA receptors. Several neurodegenerative and neuropsychiatric disorders, including Parkinson, Huntington and addiction related diseases, manifest a dysregulation of glutamate and DA signaling. Here, we will focus our attention on the mechanisms underlying the modulation of the glutamatergic transmission by DA in stnatal circuits.

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页数：11

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