Neonatal outcomes of very preterm infants admitted to a tertiary center in Lithuania between the years 2003 and 2005

被引:11
作者
Jakuskiene, Rita [1 ]
Vollmer, Brigitte [2 ]
Saferis, Viktoras [3 ]
Daugeliene, Dalia [4 ]
机构
[1] Lithuanian Univ Hlth Sci, Dept Neonatol, LT-50028 Kaunas, Lithuania
[2] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden
[3] Lithuanian Univ Hlth Sci, Dept Phys Math & Biophys, LT-50028 Kaunas, Lithuania
[4] Astrid Lindgren Childrens Hosp, Dept Pediat Neurol, Stockholm, Sweden
关键词
Very preterm; Extremely preterm; Neonatal morbidity; Neonatal mortality; Outcome; LOW-BIRTH-WEIGHT; BRONCHOPULMONARY DYSPLASIA; NEURODEVELOPMENTAL OUTCOMES; INTRAVENTRICULAR HEMORRHAGE; PREMATURE-INFANTS; GESTATIONAL-AGE; RISK-FACTORS; MORTALITY; MORBIDITY; SURVIVAL;
D O I
10.1007/s00431-011-1431-8
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The objectives of the study are to investigate gestational age-specific mortality and neonatal outcomes in preterm infants admitted to a tertiary center in Lithuania, and to make comparison with tertiary centers in western countries. Three hundred thirty-eight newborns born at a parts per thousand currency sign32 weeks of gestation and with birth weight a parts per thousand currency sign1,500 g between 1 January 2003 and 31 December 2005, admitted to the neonatal intensive care unit at Kaunas Medical University Hospital, were prospectively investigated. Mortality and associations between maternal, perinatal, and neonatal variables and short-term outcomes were examined for two gestational age (GA) groups (group I, extremely preterm, 22-27 weeks GA; group II, very preterm, 28-32 weeks GA). Mortality in group I was 53.5% and 2.9% in group II. GA < 28 weeks, Apgar score < 5 at 5 min, and birth weight < 1,000 g posed the highest risk for death. Overall, 78.2% of the surviving infants were discharged from hospital without adverse short-term outcomes. The incidence of bronchopulmonary dysplasia (BPD) was 6.3%, of retinopathy of prematurity (ROP) requiring treatment 4.2%, of intraventricular hemorrhage (IVH) III-IV 10.9%, and for cystic periventricular leukomalacia (cPVL) 8.0%. In conclusion, a decade after introduction of perinatal programs, mortality in the very preterm group is similar to those reported from cohorts in western countries. In the extremely preterm group, however, mortality is still higher. Neonatal outcomes such as ROP are now similar, and BPD is lower to those in other cohorts, whereas the incidence of brain lesions is still higher. We speculate that differences in outcomes between studies may be explained by differences in resources, definitions, and treatment routines.
引用
收藏
页码:1293 / 1303
页数:11
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