Alterations in the density of interstitial cells of Cajal in achalasia

被引：16

作者：

Kilic, Arman ^{[1
]}

Luketich, James D. ^{[1
]}

Landreneau, Rodney J. ^{[1
]}

Owens, Scott R. ^{[2
]}

Krasinskas, Alyssa M. ^{[2
]}

Schuchert, Matthew J. ^{[1
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Heart Lung & Esophageal Surg Inst, Pittsburgh, PA 15232 USA

[2] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15232 USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 06期

关键词：

achalasia; motility; esophageal; interstitial cells Cajal; ICC; megaesophagus;

D O I：

10.1007/s10620-007-0053-5

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The aim of this study was to assess the quantity of interstitial cells of Cajal (ICC) in the lower esophageal sphincter (LES) in achalasia. LES muscle was obtained from 11 achalasia and nine esophageal cancer (control) patients during surgery. Immunohistochemistry was performed and average cell counts per high-power field (HPF) were obtained. Overall, more ICC were observed in achalasia (median = 14.0 cells/HPF; range 0-22.6 cells/ HPF) as compared with controls (median = 6.2 cells/HPF; range = 1.6-10.8 cells/HPF) (P = 0.047). There were two subsets of findings within the achalasia group: 8/11(73%) had an increased quantity of ICC (median = 17.1 cells/ HPF; range = 11.6-22.6; P = 0.015) as compared with controls, whereas the remaining 3/11(27%) had a paucity of ICC (median = 0 cells/HPF; range = 0-2; P = 0.02). ICC levels were positively correlated with age of the patient (P = 0.043). Our study demonstrates that subsets of abnormal ICC levels are observed in idiopathic achalasia of the esophagus.

引用

页码：1488 / 1492

页数：5

共 30 条

[1] Variations in inflammation and nerve fiber loss reflect different subsets of achalasia patients [J].

Arman, Kilic ;

Krasinskas, Alyssa M. ;

Owens, Scott R. ;

Luketich, James D. ;

Landreneau, Rodney J. ;

Schuchert, Matthew J. .

JOURNAL OF SURGICAL RESEARCH, 2007, 143 (01) :177-182

[2] Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis [J].

Battaglia, Edda ;

Bassotti, Gabrio ;

Bellone, Graziella ;

Dughera, Luca ;

Serra, Anna Maria ;

Chiusa, Luigi ;

Repici, Alessandro ;

Mioli, Pierroberto ;

Emanuelli, Giorgio .

WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (38) :6172-6177

[3] VIP AND ACETYLCHOLINE - NEUROTRANSMITTERS IN ESOPHAGEAL CIRCULAR SMOOTH-MUSCLE [J].

BEHAR, J ;

GUENARD, V ;

WALSH, JH ;

BIANCANI, P .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (03) :G380-G385

[4] ACHALASIA AND DIFFUSE ESOPHAGEAL SPASM [J].

CASTELL, DO .

ARCHIVES OF INTERNAL MEDICINE, 1976, 136 (05) :571-579

[5]

CASTELL DO, 1990, GASTROENTEROL CLIN N, V19, P235

[6] Electrical coupling between the myenteric interstitial cells of Cajal and adjacent muscle layers in the guinea-pig gastric antrum [J].

Cousins, HM ;

Edwards, FR ;

Hickey, H ;

Hill, CE ;

Hirst, GDS .

JOURNAL OF PHYSIOLOGY-LONDON, 2003, 550 (03) :829-844

[7] Identification of rhythmically active cells in guinea-pig stomach [J].

Dickens, EJ ;

Hirst, GDS ;

Tomita, T .

JOURNAL OF PHYSIOLOGY-LONDON, 1999, 514 (02) :515-531

[8] Chest pain in achalasia: Patient characteristics and clinical course [J].

Eckardt, VF ;

Stauf, B ;

Bernhard, G .

GASTROENTEROLOGY, 1999, 116 (06) :1300-1304

[9] Plasticity of interstitial cells of Cajal: a study of mouse colon [J].

Faussone-Pellegrini, Maria-Simonetta ;

Vannucchi, Maria-Giuliana ;

Ledder, Oren ;

Huang, Tian-Ying ;

Hanani, Menachem .

CELL AND TISSUE RESEARCH, 2006, 325 (02) :211-217

[10] Chronic intestinal pseudoobstruction associated with altered interstitial cells of Cajal networks [J].

Feldstein, AE ;

Miller, SM ;

El-Youssef, M ;

Rodeberg, D ;

Lindor, NM ;

Burgart, LJ ;

Szurszewski, JH ;

Farrugia, G .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2003, 36 (04) :492-497

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