VGF Expression by Monocytes in Patients with Alzheimer's Disease and Vascular Dementia

被引：1

作者：

Busse, Stefan ^{[1
]}

Meyer, Eva ^{[1
]}

Dobrowolny, Henrik ^{[1
]}

Mawrin, Christian ^{[2
]}

Hartig, Roland ^{[3
]}

Bogerts, Bernhard ^{[1
]}

Busse, Mandy ^{[1
,4
]}

机构：

[1] Univ Magdeburg, Dept Psychiat, Leipziger Str 44, D-39120 Magdeburg, Germany

[2] Univ Magdeburg, Dept Neuropathol, Magdeburg, Germany

[3] Univ Magdeburg, Inst Mol & Clin Immunol, Magdeburg, Germany

[4] Univ Magdeburg, Expt Obstet & Gynecol, Magdeburg, Germany

来源：

GEROPSYCH-THE JOURNAL OF GERONTOPSYCHOLOGY AND GERIATRIC PSYCHIATRY | 2022年 / 35卷 / 03期

关键词：

Alzheimer's disease; vascular dementia; monocytes; VGF; biomarker; MICROGLIA; PEPTIDES; AGE;

D O I：

10.1024/1662-9647/a000263

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Because its secretion is changed in cerebrospinal fluid and peripheral blood, the neuronal polypeptide VGF (nonacronymic) has been discussed as a biomarker for neuropsychiatric disorders. We have shown an enhanced VGF expression by T-cells from Alzheimer's disease (AD) patients. In this study, we investigated the VGF expression by peripheral monocytes in 38 AD patients, 5 patients with vascular dementia (VD), and 20 neuropsychiatrically healthy individuals using flow cytometry. We determined an enhanced number of VGF-expressing monocytes in VD patients compared to AD patients. VGF+CD14+ monocytes were not correlated with age, body mass index, Mini-Mental State Examination (MMSE), or Q albumin. These preliminary data support findings indicating that VGF might play a rote as a peripheral biomarker in VD.

引用

页码：149 / 155

页数：7

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