Amino acid transporters: Emerging roles in drug delivery for tumor-targeting therapy

被引:30
作者
Zhang, Ling [1 ]
Sui, Chengguang [1 ]
Yang, Wenhan [2 ,3 ]
Luo, Qiuhua [2 ,3 ]
机构
[1] China Med Univ, Dept Biotherapy, Affiliated Hosp 1, Shenyang 110001, Peoples R China
[2] China Med Univ, Dept Pharm, Affiliated Hosp 1, 155 Nanjing North St, Shenyang 110001, Peoples R China
[3] China Med Univ, Dept Pharm, Shenyang 110001, Peoples R China
基金
中国国家自然科学基金;
关键词
Amino acid transporter; Tumor-targeting; Drug delivery; Prodrug; Nanocarriers; COUPLED ACTIVE-TRANSPORT; NEUTRON-CAPTURE THERAPY; 1 UTILIZING PRODRUGS; CELLULAR UPTAKE; MODIFIED NANOPARTICLES; GLUTAMINE ADDICTION; DOCETAXEL DELIVERY; LOADED LIPOSOMES; ATB(0; SLC6A14; CD98; EXPRESSION;
D O I
10.1016/j.ajps.2019.12.002
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Amino acid transporters, which play a vital role in transporting amino acids for the biosynthesis of mammalian cells, are highly expressed in types of tumors. Increasing studies have shown the feasibility of amino acid transporters as a component of tumor-targeting therapy. In this review, we focus on tumor-related amino acid transporters and their potential use in tumor-targeting therapy. Firstly, the expression characteristics of amino acid transporters in cancer and their relationship with tumor growth are reviewed. Secondly, the recognition requirements are discussed, focusing on the "acid-base" properties, conformational isomerism and structural analogues. Finally, recent developments in amino acid transporter-targeting drug delivery strategies are highlighted, including prodrugs and nanocarriers, with special attention to the latest findings of molecular mechanisms and targeting efficiency of transporter-mediated endocytosis. We aim to offer related clues that might lead to valuable tumor-targeting strategies by the utilization of amino acid transporters. (C) 2020 Published by Elsevier B.V. on behalf of Shenyang Pharmaceutical University.
引用
收藏
页码:192 / 206
页数:15
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