Role of Diabetes Mellitus on Treatment Effects in Drug-susceptible Initial Pulmonary Tuberculosis Patients in China

被引：7

作者：

Ma Yan ^{[1
,2
,3
]}

Huang Mai Ling ^{[1
,2
,3
]}

Li Tao ^{[4
]}

Du Jian ^{[1
,2
,3
]}

Shu Wei ^{[1
,2
,3
]}

Xie Shi Heng ^{[1
,2
,3
]}

Wang Hong Hong ^{[1
,2
,3
]}

Zhu Guo Feng ^{[5
]}

Tan Shou Yong ^{[6
]}

Fu Yan Yong ^{[7
]}

Ma Li Ping ^{[8
]}

Zhang Lian Ying ^{[9
]}

Liu Fei Ying ^{[10
]}

Hu Dai Yu ^{[11
]}

Zhang Yan Ling ^{[12
]}

Li Xiang Qun ^{[5
]}

Liu Yu Hong ^{[1
,2
,3
]}

Li Liang ^{[1
,2
,3
]}

机构：

[1] Capital Med Univ, Beijing Chest Hosp, Beijing 101149, Peoples R China

[2] Beijing TB & Thorac Tumor Res Inst, Beijing 101149, Peoples R China

[3] Chinese Ctr Dis Control & Prevent, Clin Ctr TB Control, Adm Off, Beijing 101149, Peoples R China

[4] Chinese Ctr Dis Control & Prevent, Natl Ctr TB Control & Prevent, Beijing 102206, Peoples R China

[5] Shanghai Municipal Ctr Dis Control & Prevent, Shanghai 200336, Peoples R China

[6] Guangzhou Chest Hosp, Guangzhou 510095, Guangdong, Peoples R China

[7] Tianjin Ctr Dis Control & Prevent, Tianjin 300041, Peoples R China

[8] Henan Ctr Dis Control & Prevent, Dept TB Control, Zhengzhou 450016, Henan, Peoples R China

[9] Hebei Ctr Dis Control & Prevent, Shijiazhuang 050021, Hebei, Peoples R China

[10] Guangxi Ctr Dis Control & Prevent, Dept TB Control, Nanning 530021, Guangxi, Peoples R China

[11] Chongqing AntiTB Inst, Chongqing 400050, Peoples R China

[12] Yunnan Ctr Dis Control & Prevent, Kunming 650022, Yunnan, Peoples R China

来源：

BIOMEDICAL AND ENVIRONMENTAL SCIENCES | 2017年 / 30卷 / 09期

关键词：

Tuberculosis; Diabetes mellitus; Treatment outcome;

D O I：

10.3967/bes2017.089

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

We assessed the role of diabetes mellitus (DM) on treatment effects in drug-susceptible initial pulmonary tuberculosis (PTB) patients. A prospective study was conducted in eight provinces of China from October 2008 to December 2010. We enrolled 1,313 confirmed drug-susceptible initial PTB patients, and all subjects received the treatment regimen (2H(3)R(3)E(3)Z(3)/4H(3)R(3)) as recommended by the national guidelines. Of the 1,313 PTB patients, 157 (11.9%) had DM; these patients had more sputum smear-positive rates at the end of the second month [adjusted odds ratios (aOR) 2.829, 95% confidence intervals (CI) 1.783-4.490], and higher treatment failure (aOR 2.120, 95% CI 1.565-3.477) and death rates (aOR 1.536, 95% CI 1.011-2.628). DM was a contributing factor for culture-positive rates at the end of the second month and treatment failure and death of PTB patients, thus playing an unfavorable role in treatment effects of PTB.

引用

页码：671 / 675

页数：5

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