共 78 条
Designer Biomaterials to Model Cancer Cell Invasion In Vitro: Predictive Tools or Just Pretty Pictures?
被引:9
作者:

Bahlmann, Laura C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
Univ Toronto, Terrance Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada
Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E5, Canada Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada

Smith, Laura J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
Univ Toronto, Terrance Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada
Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E5, Canada Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada

Shoichet, Molly S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
Univ Toronto, Terrance Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada
Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E5, Canada
Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
机构:
[1] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
[2] Univ Toronto, Terrance Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada
[3] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E5, Canada
[4] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
基金:
加拿大健康研究院;
加拿大自然科学与工程研究理事会;
关键词:
cancer cocultures;
cell invasion;
engineered hydrogels;
extracellular matrix;
tumor stromas;
EXTRACELLULAR-MATRIX;
TUMOR-MODEL;
CARCINOMA-CELLS;
STEM-CELL;
MIGRATION;
MICROENVIRONMENT;
MACROPHAGES;
HYDROGELS;
FIBROBLASTS;
HYALURONAN;
D O I:
10.1002/adfm.201909032
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Metastasis is the leading cause of mortality in cancer patients. Underlying this process is the invasion and colonization of cancer cells into healthy tissues. Engineered hydrogel models of tumor microenvironments present an opportunity to understand the microenvironmental determinants of cellular invasion. The biochemical and mechanical cues, presented in the form of adhesion sites, degradable cues, matrix stiffness, and architecture, have significant effects on the extent of cancer cell migration, and the mechanisms employed by these cells to move through their matrix. Coculture with stromal cells such as cancer associated fibroblasts, endothelial cells, and immune cells that are associated with poor prognosis demonstrate that these cells exacerbate cancer cell invasion. With these models, researchers aim not only to recapitulate known cancer cell behaviors in a dish, but also to uncover new insights into mechanisms underlying these phenomena, paving the way for novel treatment strategies. In this perspective, the design of engineered models that are used to study cancer cell invasion and metastasis in vitro is discussed. To this end, the authors seek to understand and put into perspective: do these models reveal relevant mechanisms of cancer cell migration, or are they simply pretty pictures with little biological translatability?
引用
收藏
页数:11
相关论文
共 78 条
- [1] Tumor macrophages are pivotal constructors of tumor collagenous matrix[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2016, 213 (11) : 2315 - 2331论文数: 引用数: h-index:机构:Zigmond, Ehud论文数: 0 引用数: 0 h-index: 0机构: Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Res Ctr Digest Tract & Liver Dis, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, IsraelVugman, Milena论文数: 0 引用数: 0 h-index: 0机构: Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Res Ctr Digest Tract & Liver Dis, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, IsraelKlepfish, Mordehay论文数: 0 引用数: 0 h-index: 0机构: Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, Israel Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, IsraelShimshoni, Elee论文数: 0 引用数: 0 h-index: 0机构: Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, Israel Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, IsraelPasmanik-Chor, Metsada论文数: 0 引用数: 0 h-index: 0机构: Tel Aviv Univ, George S Wise Fac Life Sci, Bioinformat Unit, IL-69978 Tel Aviv, Israel Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, IsraelShenoy, Anjana论文数: 0 引用数: 0 h-index: 0机构: Tel Aviv Univ, Sackler Fac Med, Dept Human Mol Genet & Biochem, IL-69978 Tel Aviv, Israel Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, Israel论文数: 引用数: h-index:机构:Halpern, Zamir论文数: 0 引用数: 0 h-index: 0机构: Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Res Ctr Digest Tract & Liver Dis, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, IsraelGeiger, Tamar论文数: 0 引用数: 0 h-index: 0机构: Tel Aviv Univ, Sackler Fac Med, Dept Human Mol Genet & Biochem, IL-69978 Tel Aviv, Israel Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, Israel论文数: 引用数: h-index:机构:Varol, Chen论文数: 0 引用数: 0 h-index: 0机构: Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Res Ctr Digest Tract & Liver Dis, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, Israel
- [2] Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform[J]. BIOMATERIALS, 2011, 32 (31) : 7913 - 7923Ananthanarayanan, Badriprasad论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA Univ Calif Berkeley, Calif Inst Quantitat Biosci, Berkeley, CA 94720 USA Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USAKim, Yushan论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA Univ Calif Berkeley, Calif Inst Quantitat Biosci, Berkeley, CA 94720 USA Univ Calif Berkeley, UCSF Grad Program Bioengn, Berkeley, CA 94720 USA Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USAKumar, Sanjay论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA Univ Calif Berkeley, Calif Inst Quantitat Biosci, Berkeley, CA 94720 USA Univ Calif Berkeley, UCSF Grad Program Bioengn, Berkeley, CA 94720 USA Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
- [3] Role of ErbB Receptors in Cancer Cell Migration and Invasion[J]. FRONTIERS IN PHARMACOLOGY, 2015, 6Appert-Collin, Aline论文数: 0 引用数: 0 h-index: 0机构: Univ Reims, UMR 7369, Unite Matrice Extracellulaire & Dynam Cellulaire, CNRS, Reims, France Univ Reims, UMR 7369, Unite Matrice Extracellulaire & Dynam Cellulaire, CNRS, Reims, FranceHubert, Pierre论文数: 0 引用数: 0 h-index: 0机构: CNRS, Lab Ingn Syst Macromol, AMU, UMR 7255, Marseille, France Univ Reims, UMR 7369, Unite Matrice Extracellulaire & Dynam Cellulaire, CNRS, Reims, FranceCremel, Gerard论文数: 0 引用数: 0 h-index: 0机构: INSERM, U1109, MN3T, Strasbourg, France Univ Reims, UMR 7369, Unite Matrice Extracellulaire & Dynam Cellulaire, CNRS, Reims, FranceBennasroune, Amar论文数: 0 引用数: 0 h-index: 0机构: Univ Reims, UMR 7369, Unite Matrice Extracellulaire & Dynam Cellulaire, CNRS, Reims, France Univ Lorraine, UMR 7360, Lab Interdisciplinaire Environm Continentaux, CNRS, Metz, France Univ Reims, UMR 7369, Unite Matrice Extracellulaire & Dynam Cellulaire, CNRS, Reims, France
- [4] Cancer-associated fibroblasts lead tumor invasion through integrin-β3-dependent fibronectin assembly[J]. JOURNAL OF CELL BIOLOGY, 2017, 216 (11) : 3509 - 3520Attieh, Youmna论文数: 0 引用数: 0 h-index: 0机构: Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, France Univ Paris 06, Univ Pierre & Marie Curie, Sorbonne Univ, Inst Doctoral Studies, Paris, France Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, FranceClark, Andrew G.论文数: 0 引用数: 0 h-index: 0机构: Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, France Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, FranceGrass, Carina论文数: 0 引用数: 0 h-index: 0机构: Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, France Tech Univ Munich, Dept Biochem, Munich, Germany Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, FranceRichon, Sophie论文数: 0 引用数: 0 h-index: 0机构: Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, France Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, FrancePocard, Marc论文数: 0 引用数: 0 h-index: 0机构: Univ Paris Diderot, Sorbonne Paris Cite, Hop Lariboisiere, Chirurg Digest & Cancorol,AP HP, Paris, France Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, FranceMariani, Pascale论文数: 0 引用数: 0 h-index: 0机构: Paris Sci & Lettres Res Univ, Inst Curie, Dept Surg, Paris, France Paris Sci & Lettres Res Univ, Inst Curie, Dept Surg, St Cloud, France Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, FranceElkhatib, Nadia论文数: 0 引用数: 0 h-index: 0机构: Univ Paris Saclay, Gustave Roussy Inst, INSERM, U1170, Villejuif, France Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, FranceBetz, Timo论文数: 0 引用数: 0 h-index: 0机构: Munster Univ, Inst Cell Biol, Cells In Mot Cluster Excellence, Ctr Mol Biol Inflammat, Munster, Germany Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, FranceGurchenkov, Basile论文数: 0 引用数: 0 h-index: 0机构: Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, France Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, FranceVignjevic, Danijela Matic论文数: 0 引用数: 0 h-index: 0机构: Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, France Paris Sci & Lettres Res Univ, Inst Curie, CNRS, UMR 144, Paris, France
- [5] 3D Traction Stresses Activate Protease-Dependent Invasion of Cancer Cells[J]. BIOPHYSICAL JOURNAL, 2014, 107 (11) : 2528 - 2537Aung, Aereas论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USASeo, Young N.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USALu, Shaoying论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USAWang, Yingxiao论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USAJamora, Colin论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA IFOM inStem Joint Res Lab, Bangalore, Karnataka, India Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USAdel Alamo, Juan C.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Mech & Aerosp Engn, La Jolla, CA USA Univ Calif San Diego, Inst Engn Med, La Jolla, CA USA Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USAVarghese, Shyni论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego, Inst Engn Med, La Jolla, CA USA IFOM inStem Joint Res Lab, Bangalore, Karnataka, India Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
- [6] Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival[J]. AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (02) : 529 - 536Auvinen, P论文数: 0 引用数: 0 h-index: 0机构: Kuopio Univ Hosp, Dept Oncol, FIN-70211 Kuopio, FinlandTammi, R论文数: 0 引用数: 0 h-index: 0机构: Kuopio Univ Hosp, Dept Oncol, FIN-70211 Kuopio, FinlandParkkinen, J论文数: 0 引用数: 0 h-index: 0机构: Kuopio Univ Hosp, Dept Oncol, FIN-70211 Kuopio, FinlandTammi, M论文数: 0 引用数: 0 h-index: 0机构: Kuopio Univ Hosp, Dept Oncol, FIN-70211 Kuopio, FinlandÅgren, U论文数: 0 引用数: 0 h-index: 0机构: Kuopio Univ Hosp, Dept Oncol, FIN-70211 Kuopio, FinlandJohansson, R论文数: 0 引用数: 0 h-index: 0机构: Kuopio Univ Hosp, Dept Oncol, FIN-70211 Kuopio, FinlandHirvikoski, P论文数: 0 引用数: 0 h-index: 0机构: Kuopio Univ Hosp, Dept Oncol, FIN-70211 Kuopio, FinlandEskelinen, M论文数: 0 引用数: 0 h-index: 0机构: Kuopio Univ Hosp, Dept Oncol, FIN-70211 Kuopio, FinlandKosma, VM论文数: 0 引用数: 0 h-index: 0机构: Kuopio Univ Hosp, Dept Oncol, FIN-70211 Kuopio, Finland
- [7] Dynamic bioengineered hydrogels as scaffolds for advanced stem cell and organoid culture[J]. MRS COMMUNICATIONS, 2017, 7 (03) : 472 - 486Bahlmann, Laura C.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S3E1, Canada Univ Toronto, Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S3E1, CanadaFokina, Ana论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada Univ Toronto, Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S3E1, CanadaShoichet, Molly S.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S3E1, Canada Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada Univ Toronto, Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S3E1, Canada
- [8] Benchmarking to the Gold Standard: Hyaluronan-Oxime Hydrogels Recapitulate Xenograft Models with In Vitro Breast Cancer Spheroid Culture[J]. ADVANCED MATERIALS, 2019, 31 (36)Baker, Alexander E. G.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, CanadaBahlmann, Laura C.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, CanadaTam, Roger Y.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, CanadaLiu, Jeffrey C.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, CanadaGanesh, Ahil N.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, CanadaMitrousis, Nikolaos论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, CanadaMarcellus, Richard论文数: 0 引用数: 0 h-index: 0机构: MaRS Ctr, Ontario Inst Canc Res, 661 Univ Ave, Toronto, ON M5G 0A3, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, CanadaSpears, Melanie论文数: 0 引用数: 0 h-index: 0机构: MaRS Ctr, Ontario Inst Canc Res, 661 Univ Ave, Toronto, ON M5G 0A3, Canada Univ Toronto, Dept Lab Med & Pathol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, CanadaBartlett, John M. S.论文数: 0 引用数: 0 h-index: 0机构: MaRS Ctr, Ontario Inst Canc Res, 661 Univ Ave, Toronto, ON M5G 0A3, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, CanadaCescon, David W.论文数: 0 引用数: 0 h-index: 0机构: Univ Hlth Network, Princess Margaret Canc Ctr, 610 Univ Ave, Toronto, ON M5G 2C1, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, CanadaBader, Gary D.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, CanadaShoichet, Molly S.论文数: 0 引用数: 0 h-index: 0机构: Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada Univ Toronto, Dept Chem Engn & Appl Chem, 200 Coll St, Toronto, ON M5S 3E5, Canada Inst Biomat & Biomed Engn, 164 Coll St, Toronto, ON M5S 3G9, Canada Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada
- [9] Advantages of RGD peptides for directing cell association with biomaterials[J]. BIOMATERIALS, 2011, 32 (18) : 4205 - 4210Bellis, Susan L.论文数: 0 引用数: 0 h-index: 0机构: Univ Alabama Birmingham, Dept Physiol & Biophys, Birmingham, AL 35294 USA Univ Alabama Birmingham, Dept Physiol & Biophys, Birmingham, AL 35294 USA
- [10] Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis[J]. JOURNAL OF PATHOLOGY, 2015, 237 (03) : 273 - 281Brown, Gordon T.论文数: 0 引用数: 0 h-index: 0机构: Univ Aberdeen, Sch Med & Dent, Div Appl Med, Pathol, Aberdeen AB25 2ZD, Scotland Univ Aberdeen, Sch Med & Dent, Div Appl Med, Pathol, Aberdeen AB25 2ZD, ScotlandMurray, Graeme I.论文数: 0 引用数: 0 h-index: 0机构: Univ Aberdeen, Sch Med & Dent, Div Appl Med, Pathol, Aberdeen AB25 2ZD, Scotland Univ Aberdeen, Sch Med & Dent, Div Appl Med, Pathol, Aberdeen AB25 2ZD, Scotland