YAP-(S)PET small animal scanner: Quantitative results

被引：15
作者：
Di Domenico, G [1 ]
Zavattini, G
Moretti, E
Piffanelli, A
Giganti, M
Motta, A
Sabba, N
Uccelli, L
Benini, E
Duatti, A
Bolzati, C
Boschi, A
Del Guerra, A
机构：
[1] Univ Ferrara, Dept Phys, I-44100 Ferrara, Italy
[2] Ist Nazl Fis Nucl, I-44100 Ferrara, Italy
[3] Univ Ferrara, Dept Clin & Expt Med, I-44100 Ferrara, Italy
[4] Univ Pisa, Dept Phys, I-56100 Pisa, Italy
来源：
IEEE TRANSACTIONS ON NUCLEAR SCIENCE | 2003年 / 50卷 / 05期
关键词：
calibration; cardiac radiotracers; image processing; quantitation; single photon emission computed tomography; (SPECT); small animal imaging; tomography;
D O I：
10.1109/TNS.2003.817970
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
The University of Ferrara YAP-(S)PET scanner is currently being employed in small animal SPECT studies, with Tc-99 m labeled radiotracers, with the goal of obtaining quantitative activity measurements from region of interest (ROI) analysis of reconstructed images of rats. The measurements will be compared directly with traditional ex vivo measurement of activity with gamma counters. To achieve this goal, the scanner was calibrated relative to a standard Isodose dose calibrator which was calibrated with various certified activity sources. The calibration factor K was defined as the ratio of the activity measured with the Isodose (MBq) and the image count rate (cps). We find K = 0.1346 +/- 0.0008 MBq/cps, with good linearity over a wide range of activities (9-88 MBq). With the calibrated scanner we compared results of activity measurements from images of whole-rat heart acquisitions versus excised hearts. We found good agreement between the two measurements.
引用
收藏
页码：1351 / 1356
页数：6
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