Biomedical applications of magneto-responsive scaffolds

被引:76
作者
Adedoyin, Adedokun A. [1 ]
Ekenseair, Adam K. [1 ]
机构
[1] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA
关键词
biomaterials; magnetic nanoparticles; magneto-responsive scaffolds; regenerative medicine; stimuli-responsive materials; tissue engineering; IRON-OXIDE NANOPARTICLES; CARBOXYMETHYL CHITOSAN; DRUG-DELIVERY; HYDROGELS; RELEASE; SHAPE; HYPERTHERMIA; DOXORUBICIN; FABRICATION; CELLS;
D O I
10.1007/s12274-018-2198-2
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Stimuli-responsive biomaterials, capable of responding on-demand to changes in their local environment, have become a subject of interest in the field of regenerative medicine. Magneto-responsive biomaterials, which can be manipulated spatiotemporally via an external magnetic field, have emerged as promising candidates as active scaffolds for advanced drug delivery and tissue regeneration applications. These specialized biomaterials can be synthesized by physically and/or chemically incorporating magnetic nanoparticles into the biomaterial structure. However, despite their promising impact on the future of regenerative medicine, magneto-responsive biomaterials still have several limitations that need to be overcome before they can be implemented clinically in a reliable manner, as predicting their behavior and biocompatibility remains an ongoing challenge. This review article will focus on discussing the current fabrication methods used to synthesize magneto-responsive materials, efforts to predict and characterize magneto-responsive biomaterial behavior, and the application of magneto-responsive biomaterials as controlled drug delivery systems, tissue engineering scaffolds, and artificial muscles.
引用
收藏
页码:5049 / 5064
页数:16
相关论文
共 97 条
[91]   Magnetic nanoparticle-loaded electrospun polymeric nanofibers for tissue engineering [J].
Zhang, Heng ;
Xia, JiYi ;
Pang, XianLun ;
Zhao, Ming ;
Wang, BiQiong ;
Yang, LingLin ;
Wan, HaiSu ;
Wu, JingBo ;
Fu, ShaoZhi .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 73 :537-543
[92]   A pH-Sensitive Nanosystem Based on Carboxymethyl Chitosan for Tumor-Targeted Delivery of Daunorubicin [J].
Zhang, Xueqiong ;
Zhang, Hong ;
Yin, Liangquan ;
Hu, Rui ;
Qiu, Tong ;
Yin, Yihua ;
Xiong, Xiong ;
Zheng, Hua ;
Wang, Qun .
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2016, 12 (08) :1688-1698
[93]   Active scaffolds for on-demand drug and cell delivery [J].
Zhao, Xuanhe ;
Kim, Jaeyun ;
Cezar, Christine A. ;
Huebsch, Nathaniel ;
Lee, Kangwon ;
Bouhadir, Kamal ;
Mooney, David J. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (01) :67-72
[94]   Redox Sensitive Shell and Core Crosslinked Hyaluronic Acid Nanocarriers for Tumor-Targeted Drug Delivery [J].
Zheng, Hua ;
Yin, Liangquan ;
Zhang, Xueqiong ;
Zhang, Hong ;
Hu, Rui ;
Yin, Yihua ;
Qiu, Tong ;
Xiong, Xiong ;
Wang, Qun .
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2016, 12 (08) :1641-1653
[95]   Hierarchically Structured Free-Standing Hydrogels with Liquid Crystalline Domains and Magnetic Nanoparticles as Dual Physical Cross-Linkers [J].
Zhou, Yuxiang ;
Sharma, Nitin ;
Deshmukh, Prashant ;
Lakhman, Rubinder Kaur ;
Jain, Menka ;
Kasi, Rajeswari M. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (03) :1630-1641
[96]   Kinetics of the shape change of magnetic field sensitive polymer gels [J].
Zrínyi, M ;
Szabó, D ;
Kilian, HG .
POLYMER GELS AND NETWORKS, 1998, 6 (06) :441-454
[97]   Intelligent polymer gels controlled by magnetic fields [J].
Zrínyi, M .
COLLOID AND POLYMER SCIENCE, 2000, 278 (02) :98-103