Advances in Green Catalysis for the Synthesis of Medicinally Relevant N-Heterocycles

被引:13
作者
Santos, A. Sofia [1 ]
Raydan, Daniel [1 ]
Cunha, Jose C. [1 ]
Viduedo, Nuno [1 ]
Silva, Artur M. S. [2 ]
Marques, M. Manuel B. [1 ]
机构
[1] Univ Nova Lisboa, NOVA Sch Sci & Technol, Dept Quim, LAQV REQUIMTE, Campus Caparica, P-2829516 Caparica, Portugal
[2] Univ Aveiro, Dept Chem, LAQV REQUIMTE, P-3810193 Aveiro, Portugal
关键词
green catalysis; N-heterocycles; synthesis; bioactive compounds; metal-catalysis; ONE-POT SYNTHESIS; CONSTRUCTION; 7-AZAINDOLES; LEUKEMIA; AMINOALKYLATION; AMINOPYRIDINES; DERIVATIVES; REACTIVITY; ALKENES; ACCESS;
D O I
10.3390/catal11091108
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
N-heterocycles, both saturated and unsaturated, are ubiquitous biologically active molecules that are extremely appealing scaffolds in drug discovery programs. Although classical synthetic methods have been developed to access many relevant N-heterocyclic scaffolds, representing well-established and reliable routes, some do not meet the needs of sustainability. In this context, several advances have been made towards the sustainable synthesis of N-heterocycles. This review focuses on the most recent examples from the last five years of catalytic synthesis of several heterocyclic compounds of medicinal relevance. Thus, the synthesis of isoindoloquinazolines, quinazolines and azaindoles, among others, are covered. The synthetic methods selected include the use of homogeneous and heterogeneous catalysts and the use of alternative and sustainable methods such as, for example, metal-catalyzed acceptorless coupling and one-pot reactions. The green aspects of the individual synthetic approaches are highlighted, and the scope of each methodology is described.
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页数:21
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