Anti-cytokine vaccination in autoimmune diseases

被引：28

作者：

Delavallee, Laure

Duvallet, Emilie

Semerano, Luca

Assier, Eric

Boissier, Marie-Christophe ^{[1
]}

机构：

[1] Univ Paris 13, PRES Paris Cite Sorbonne, Bobigny, France

来源：

SWISS MEDICAL WEEKLY | 2010年 / 140卷

关键词：

Cytokine blockade; anti-TNF therapy; vaccination; autoimmunity; rheumatoid arthritis;

D O I：

10.4414/smw.2010.13108

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The concept of therapeutic vaccination represents a novel strategy of active immunotherapy that can be applied to autoimmune disease The principle is to design molecules which can trigger an immune response, targeting a cytokine that is pathogenic and over-expressed in a given disease The mostly available vaccines are an application of vaccination using either the self-protein coupled to a carrier (type I A), or a modified form of the protein engineered to include neo-epitopes (type I B) These approaches have been developed in models of several autoimmune diseases, mainly in TNF alpha-dependent diseases such as rheumatoid arthritis and Crohn's disease, but also in systemic lupus erythematosus, multiple sclerosis and myasthenia gravis Clinical trials are in progress in rheumatoid arthritis, Crohn's disease and diabetes The benefit/risk ratio of anti-cytokine vaccination is currently under study to further develop the vaccination strategies

引用

页码：28 / 32

页数：5

共 52 条

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