Vitamin D Receptor Polymorphisms in Type 2 Diabetes in Southeastern Iranian Patients

被引：16

作者：

Nosratabadi, Reza ^{[1
]}

Arababadi, Mohammad Kazemi ^{[2
]}

Salehabad, Vajihe Akbarpour ^{[3
]}

机构：

[1] Islamic Azad Univ, Zahedan Branch, Fac Med, Dept Lab Sci, Zahedan, Iran

[2] Rafsanjan Univ Med Sci, Dept Microbiol Hematol & Immunol, Rafsanjan, Iran

[3] Rafsanjan Univ Med Sci, Mol Med Res Ctr, Rafsanjan, Iran

来源：

LABMEDICINE | 2011年 / 42卷 / 01期

关键词：

VDR polymorphism; type; 2; diabetes; GENE POLYMORPHISMS; 1,25-DIHYDROXYVITAMIN D-3; DEVELOPMENTAL ORIGINS; MELLITUS; ASSOCIATION; GAMMA;

D O I：

10.1309/LMW788XEEYVVLBUV

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background The impact of several environmental and genetic factors on diabetes is well documented The present study was aimed to examine the 2 single nucleotide polymorphisms (SNP) in intron 8 and exon 9 of the vitamin D receptor (VDR) gene in type 2 diabetic patients Material and Methods In this clinical study peripheral blood samples were obtained from 100 type 2 diabetic patients and 100 healthy controls DNA was extracted and polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) was performed to examine 2 SNP polymorphisms within the VDR gene Results Our results showed a significant difference in the Taq1 evaluated genotype of exon 9 in the VDR gene but no significant differences were seen regarding other examined genotypes and alleles Conclusion Based on our results, it can be concluded that VDR and its functional polymorphism in exon 9 may play an important role in the pathogenesis of type 2 diabetes

引用

页码：32 / 34

页数：3

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