COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men

被引：26
作者：
Demonbreun, Alexis R. [1 ,2 ]
Sancilio, Amelia [3 ,4 ]
Velez, Matt E. [1 ,5 ]
Ryan, Daniel T. [6 ,7 ]
Pesce, Lorenzo [1 ,2 ]
Saber, Rana [6 ,7 ]
Vaught, Lauren A. [1 ,5 ]
Reiser, Nina L. [1 ,5 ]
Hsieh, Ryan R. [1 ,5 ]
D'Aquila, Richard T. [8 ]
Mustanski, Brian [6 ,7 ]
McDade, Thomas W. [3 ,4 ]
McNally, Elizabeth M. [1 ,5 ,9 ]
机构：
[1] Northwestern Univ, Ctr Genet Med, Feinberg Sch Med, Chicago, IL 60611 USA
[2] Northwestern Univ, Dept Pharmacol, Feinberg Sch Med, Chicago, IL 60611 USA
[3] Northwestern Univ, Dept Anthropol, Evanston, IL 60611 USA
[4] Northwestern Univ, Inst Policy Res, Evanston, IL 60611 USA
[5] Northwestern Univ, Dept Med, Div Cardiol, Feinberg Sch Med, Chicago, IL 60611 USA
[6] Inst Sexual & Gender Minor Hlth & Wellbeing, Chicago, IL USA
[7] Northwestern Univ, Dept Med Social Sci, Chicago, IL 60611 USA
[8] Northwestern Univ, Dept Med, Div Infect Dis, Feinberg Sch Med, Chicago, IL 60611 USA
[9] Northwestern Univ, Dept Biochem & Mol Genet, Chicago, IL 60611 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2021年 / 224卷 / 05期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
COVID-19; SARS-CoV-2; serological testing; IgG; ELISA; dried blood spots; vaccine; neutralizing; receptor binding domain;
D O I：
10.1093/infdis/jiab314
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 mu g/mL, 51.6% vs 3.3 mu g/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 mu g/mL) compared to men (20.6 mu g/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.
引用
收藏
页码：793 / 797
页数：5
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