Efficacy of a reduced dose of darunavir/ritonavir in a cohort of antiretroviral-naive and -experienced HIV-infected patients: a medium-term follow-up

被引:8
作者
Lanzafame, Massimiliano [1 ]
Lattuada, Emanuela [1 ]
Rigo, Fabio [1 ]
Ferrari, Anna [1 ]
Hill, Andrew [2 ]
Vento, Sandro [3 ]
机构
[1] GB Rossi Hosp, Infect Dis Unit, Verona, Italy
[2] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3BX, Merseyside, England
[3] Univ Botswana, Fac Med, Dept Internal Med, Gaborone, Botswana
关键词
antiviral; dose optimization; pharmacokinetics; DARUNAVIR-RITONAVIR; SAFETY; WEEK-48; TRIALS;
D O I
10.1093/jac/dku390
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
引用
收藏
页码:627 / 630
页数:4
相关论文
共 10 条
  • [1] Population pharmacokinetic modelling and evaluation of different dosage regimens for darunavir and ritonavir in HIV-infected individuals
    Arab-Alameddine, M.
    Lubomirov, R.
    Fayet-Mello, A.
    Aouri, M.
    Rotger, M.
    Buclin, T.
    Widmer, N.
    Gatri, M.
    Ledergerber, B.
    Rentsch, K.
    Cavassini, M.
    Panchaud, A.
    Guidi, M.
    Telenti, A.
    Decosterd, L. A.
    Csajka, C.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (09) : 2489 - 2498
  • [2] Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2:: a pooled subgroup analysis of data from two randomised trials
    Clotet, Bonaventura
    Bellos, Nicholas
    Molina, Jean-Michel
    Cooper, David
    Goffard, Jean-Chrostophe
    Lazzarin, Adriano
    Woehrmann, Andrej
    Katlama, Christine
    Wilkin, Timothy
    Haubrich, Richard
    Cohen, Calvin
    Farthing, Charles
    Jayaweera, Dushyantha
    Markowitz, Martin
    Ruane, Peter
    Spinosa-Guzman, Sabrina
    Lefebvre, Eric
    [J]. LANCET, 2007, 369 (9568) : 1169 - 1178
  • [3] Resistance profile of darunavir:: Combined 24-week results from the POWER trials
    de Meyer, Sandra
    Vangeneugden, Tony
    van Baelen, Ben
    de Paepe, Els
    van Marck, Herwig
    Picchio, Gaston
    Lefebvre, Eric
    de Bethune, Marie-Pierre
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2008, 24 (03) : 379 - 388
  • [4] Di Yacovo S, 2014, 15 INT WORKSH CLIN P, P70
  • [5] Binding kinetics of darunavir to human immunodeficiency virus type 1 protease explain the potent antiviral activity and high genetic barrier
    Dierynck, Inge
    De Wit, Mieke
    Gustin, Emmanuel
    Keuleers, Inge
    Vandersmissen, Johan
    Hallenberger, Sabine
    Hertogs, Kurt
    [J]. JOURNAL OF VIROLOGY, 2007, 81 (24) : 13845 - 13851
  • [6] Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN:: a randomised controlled phase III trial
    Madruga, Jose Valdez
    Berger, Daniel
    McMurchie, Marilyn
    Suter, Fredy
    Banhegyi, Denes
    Ruxrungtham, Kiat
    Norris, Dorece
    Lefebvre, Eric
    de Bethune, Marie-Pierre
    Tomaka, Frank
    De Pauw, Martine
    Vangeneugden, Tony
    Spinoso-Guzman, Sabrina
    [J]. LANCET, 2007, 370 (9581) : 49 - 58
  • [7] Molina JM, 2007, JAIDS-J ACQ IMM DEF, V46, P24
  • [8] Molto J, 2014, 15 INT WORKSH CLIN P, P4
  • [9] Efficacy and safety of once-daily darunavir/ritonavir versus lopinavir/ritonavir in treatment-naive HIV-1-infected patients at week 48
    Ortiz, Roberto
    DeJesus, Edwin
    Khanlou, Homayoon
    Voronin, Evgeniy
    van Lunzen, Jan
    Andrade-Villanueva, Jaime
    Fourie, Jan
    De Meyer, Sandra
    De Pauw, Martine
    Lefebvre, Eric
    Vangeneugden, Tony
    Spinosa-Guzman, Sabrina
    [J]. AIDS, 2008, 22 (12) : 1389 - 1397
  • [10] Efficacy of 400 mg efavirenz versus standard 600 mg dose in HIV-infected, antiretroviral-naive adults (ENCORE1): a randomised, double-blind, placebo-controlled, non-inferiority trial
    Puls, Rebekah L.
    Amin, Janaki
    Losso, Marcelo
    Phanuphak, Praphan
    Nwizu, Chidi
    Orrell, Catherine
    Young, Barnaby
    Shahar, Eduardo
    Wolff, Marcelo
    Gazzard, Brian
    Read, Tim
    Hill, Andrew
    Cooper, David A.
    Emery, Sean
    [J]. LANCET, 2014, 383 (9927) : 1474 - 1482