Kdo: a critical monosaccharide for bacteria viability

被引：60
作者：
Cipolla, Laura [1 ]
Gabrielli, Luca [1 ]
Bini, Davide [1 ]
Russo, Laura [1 ]
Shaikh, Nasrin [1 ]
机构：
[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, I-20126 Milan, Italy
来源：
NATURAL PRODUCT REPORTS | 2010年 / 27卷 / 11期
关键词：
CMP-2-KETO-3-DEOXY-MANNO-OCTONIC ACID SYNTHETASE; ARABINOSE 5-PHOSPHATE ISOMERASE; CELL-WALL LIPOPOLYSACCHARIDE; MECHANISM-BASED INHIBITOR; P-TYPE ATPASE; ESCHERICHIA-COLI; LIPID-A; 3-DEOXY-D-MANNO-OCTULOSONATE-8-PHOSPHATE SYNTHASE; AQUIFEX-AEOLICUS; CATALYTIC MECHANISM;
D O I：
10.1039/c004750n
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Kdo belongs to the 3-deoxysugar 'family' and is a critical monosaccharidic component of lipopolysaccharides (LPSs) in Gram-negative bacteria. The incorporation of Kdo into LPSs is a vital step in the assembly of the protective outer membrane of Gram-negative bacteria. This review intends to present recent advances on structural/biocatalytic knowledge on the four enzymes involved in Kdo metabolism, and on the synthesis and biological activity of analogues of biosynthetic intermediates, highlighting the potential of this pathway for the discovery of new antibacterials - a pressing need due to the emergence of new classes of antibiotic-resistant bacteria.
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收藏
页码：1618 / 1629
页数：12
相关论文
共 158 条
[1]   Synthesis and inhibitory activity of 8-substituted 2-deoxy-β-KDO against CMP-KDO synthetase [J].
Adachi, Hayamitsu ;
Kondo, Ken-Ichiro ;
Kojima, Fukiko ;
Umezawa, Yoji ;
Ishino, Keiko ;
Hotta, Kunimoto ;
Nishimura, Yoshio .
NATURAL PRODUCT RESEARCH, 2006, 20 (04) :361-370
[2]   Targeting Bacterial Membranes: NMR Spectroscopy Characterization of Substrate Recognition and Binding Requirements of D-Arabinose-5-Phosphate Isomerase [J].
Airoldi, Cristina ;
Sommaruga, Silvia ;
Merlo, Silvia ;
Sperandeo, Paola ;
Cipolla, Laura ;
Polissi, Alessandra ;
Nicotra, Francesco .
CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (06) :1897-1902
[3]   Chemical structure of lipid A -: The primary immunomodulatory center of bacterial lipopolysaccharides [J].
Alexander, C ;
Zähringer, U .
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 2002, 14 (76) :69-86
[4]   Phosphoryl group transfer: evolution of a catalytic scaffold [J].
Allen, KN ;
Dunaway-Mariano, D .
TRENDS IN BIOCHEMICAL SCIENCES, 2004, 29 (09) :495-503
[5]   Chemical diversity in the sialic acids and related α-keto acids:: An evolutionary perspective [J].
Angata, T ;
Varki, A .
CHEMICAL REVIEWS, 2002, 102 (02) :439-469
[6]   The catalytic domain of the P-type ATPase has the haloacid dehalogenase fold [J].
Aravind, L ;
Galperin, MY ;
Koonin, EV .
TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (04) :127-129
[7]   Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor [J].
Asojo, O ;
Friedman, J ;
Adir, N ;
Belakhov, V ;
Shoham, Y ;
Baasov, T .
BIOCHEMISTRY, 2001, 40 (21) :6326-6334
[8]  
Baasov T, 2000, DRUG DEVELOP RES, V50, P416
[9]   Catalytic mechanism of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase [J].
Baasov, T ;
Tkacz, R ;
Sheffer-Dee-Noor, S ;
Belakhov, V .
CURRENT ORGANIC CHEMISTRY, 2001, 5 (02) :127-138
[10]   Structural analysis of a set of proteins resulting from a bacterial genomics project [J].
Badger, J ;
Sauder, JM ;
Adams, JM ;
Antonysamy, S ;
Bain, K ;
Bergseid, MG ;
Buchanan, SG ;
Buchanan, MD ;
Batiyenko, Y ;
Christopher, JA ;
Emtage, S ;
Eroshkina, A ;
Feil, I ;
Furlong, EB ;
Gajiwala, KS ;
Gao, X ;
He, D ;
Hendle, J ;
Huber, A ;
Hoda, K ;
Kearins, P ;
Kissinger, C ;
Laubert, B ;
Lewis, HA ;
Lin, J ;
Loomis, K ;
Lorimer, D ;
Louie, G ;
Maletic, M ;
Marsh, CD ;
Miller, I ;
Molinari, J ;
Muller-Dieckmann, HJ ;
Newman, JM ;
Noland, BW ;
Pagarigan, B ;
Park, F ;
Peat, TS ;
Post, KW ;
Radojicic, S ;
Ramos, A ;
Romero, R ;
Rutter, ME ;
Sanderson, WE ;
Schwinn, KD ;
Tresser, J ;
Winhoven, J ;
Wright, TA ;
Wu, L ;
Xu, J .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 60 (04) :787-796
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