Astrocytes' Contribution to Adult Neurogenesis in Physiology and Alzheimer's Disease

被引：82

作者：

Casse, Frederic ^{[1
]}

Richetin, Kevin ^{[1
]}

Toni, Nicolas ^{[1
]}

机构：

[1] Lausanne Univ Hosp, Dept Psychiat, Ctr Psychiat Neurosci, Lausanne, Switzerland

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2018年 / 12卷

基金：

瑞士国家科学基金会;

关键词：

neurogenesis; astrocytes; Alzheimer's disease; neurogenic niche; secretion; NEURAL STEM-CELLS; ENHANCED SYNAPTIC PLASTICITY; GLIA-LIKE CELLS; HIPPOCAMPAL NEUROGENESIS; MOUSE MODEL; REACTIVE ASTROCYTES; DENTATE GYRUS; MITOCHONDRIAL DYSFUNCTION; REGULATE NEUROGENESIS; CONNEXIN EXPRESSION;

D O I：

10.3389/fncel.2018.00432

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult neurogenesis is one of the most drastic forms of brain plasticity in adulthood and there is a growing body of evidence showing that, in the hippocampus, this process contributes to mechanisms of memory as well as depression. Interestingly, adult neurogenesis is tightly regulated by the neurogenic niche, which provides a structural and molecular scaffold for stem cell proliferation and the differentiation and functional integration of new neurons. In this review, we highlight the role of astrocytes in the regulation of adult neurogenesis in the context of cognitive function. We also discuss how the changes in astrocytes function may dysregulate adult neurogenesis and contribute to cognitive impairment in the context of Alzheimer's disease.

引用

页数：13

共 50 条

[21] Neurogenesis in mouse models of Alzheimer's disease
Chuang, Tsu Tshen
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2010, 1802 (10): : 872 - 880
[22] NEUROGENESIS AS A THERAPEUTIC TARGET FOR ALZHEIMER'S DISEASE
Fernandez-Verdecia, C. I.
Diaz del Guante, M. A.
Castillo-Diaz, L.
Alvarez-Blanco, J.
REVISTA DE NEUROLOGIA, 2009, 49 (04) : 193 - 201
[23] Optogenetics in Alzheimer's Disease: Focus on Astrocytes
Mitroshina, Elena
Kalinina, Elizaveta
Vedunova, Maria
ANTIOXIDANTS, 2023, 12 (10)
[24] Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer's disease by compromising hippocampal inhibition
Hollands, Carolyn
Tobin, Matthew Kyle
Hsu, Michael
Musaraca, Kianna
Yu, Tzong-Shiue
Mishra, Rachana
Kernie, Steven G.
Lazarov, Orly
MOLECULAR NEURODEGENERATION, 2017, 12
[25] Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice
Yan, Yufang
Ma, Tuo
Gong, Kai
Ao, Qiang
Zhang, Xiufang
Gong, Yandao
NEURAL REGENERATION RESEARCH, 2014, 9 (08) : 798 - 805
[26] Cell Therapy as a Way to Correct Impaired Neurogenesis in the Adult Brain in a Model of Alzheimer's Disease
Chaplygina, A., V
Zhdanova, D. Y.
Kovalev, V., I
Poltavtseva, R. A.
Medvinskaya, N., I
Bobkova, N., V
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY, 2022, 58 (01) : 117 - 137
[27] Implication of Adult Hippocampal Neurogenesis in Alzheimer's Disease and Potential Therapeutic Approaches
Essa, Hesham
Peyton, Lee
Hasan, Whidul
Leon, Brandon Emanuel
Choi, Doo-Sup
CELLS, 2022, 11 (02)
[28] Neurogenesis and Alzheimer's disease: At the crossroads
Lazarov, Orly
Marr, Robert A.
EXPERIMENTAL NEUROLOGY, 2010, 223 (02) : 267 - 281
[29] Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer's disease
Calio, Michele Longoni
Mosini, Amanda Cristina
Marinho, Darci Souza
Salles, Geisa Nogueira
Massinhani, Fernando Henrique
Ko, Gui Mi
Porcionatto, Marimelia Aparecida
NEUROBIOLOGY OF DISEASE, 2021, 148
[30] Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease
Sun, Binggui
Halabisky, Brian
Zhou, Yungui
Palop, Jorge J.
Yu, Guiqiu
Mucke, Lennart
Gan, Li
CELL STEM CELL, 2009, 5 (06) : 624 - 633

← 1 2 3 4 5 →