Astrocytes' Contribution to Adult Neurogenesis in Physiology and Alzheimer's Disease

被引：83

作者：

Casse, Frederic ^{[1
]}

Richetin, Kevin ^{[1
]}

Toni, Nicolas ^{[1
]}

机构：

[1] Lausanne Univ Hosp, Dept Psychiat, Ctr Psychiat Neurosci, Lausanne, Switzerland

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2018年 / 12卷

基金：

瑞士国家科学基金会;

关键词：

neurogenesis; astrocytes; Alzheimer's disease; neurogenic niche; secretion; NEURAL STEM-CELLS; ENHANCED SYNAPTIC PLASTICITY; GLIA-LIKE CELLS; HIPPOCAMPAL NEUROGENESIS; MOUSE MODEL; REACTIVE ASTROCYTES; DENTATE GYRUS; MITOCHONDRIAL DYSFUNCTION; REGULATE NEUROGENESIS; CONNEXIN EXPRESSION;

D O I：

10.3389/fncel.2018.00432

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult neurogenesis is one of the most drastic forms of brain plasticity in adulthood and there is a growing body of evidence showing that, in the hippocampus, this process contributes to mechanisms of memory as well as depression. Interestingly, adult neurogenesis is tightly regulated by the neurogenic niche, which provides a structural and molecular scaffold for stem cell proliferation and the differentiation and functional integration of new neurons. In this review, we highlight the role of astrocytes in the regulation of adult neurogenesis in the context of cognitive function. We also discuss how the changes in astrocytes function may dysregulate adult neurogenesis and contribute to cognitive impairment in the context of Alzheimer's disease.

引用

页数：13

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