Impact of obesity in intima media thickness' of carotid arteries

被引:83
作者
Kotsis, Vasilios T.
Stabouli, Stella V.
Papamichael, Christos M.
Zakopoulos, Nikos A.
机构
[1] Natl & Kapodestrial Univ, Dept Clin Therapeut, Alexandra Hosp, Athens, Greece
[2] Aristotle Univ Thessaloniki, Dept Med, Thessaloniki, Greece
[3] Natl & Kapodestrial Univ, Dept Pediat, Athens, Greece
关键词
carotid artery intima media thickness; ambulatory blood pressure monitoring; fasting glucose; BMI;
D O I
10.1038/oby.2006.196
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To explore differences in intima media thickness (IMT) of the carotid arteries induced by differences in BMI. Research Methods and Procedures: Data from 3173 consecutive subjects, who were referred to our Hypertension Center from 1998 to 2004, were reviewed. Criteria for patients to be considered for further analysis included no past or concurrent antihypertensive medication, no concurrent medication with the potential to raise blood pressure (BP) (e.g., prednisone), and no clinical signs or laboratory evidence of secondary causes of hypertension. Our population was divided into four groups according to NIH criteria for obesity: underweight, normal weight, overweight, and obese. BMI, mean IMT of internal carotid arteries, and 24-hour BP values were available for all subjects. Five hundred thirty six subjects of the four groups, matched for age, gender, and mean 24-hour BP values, were included in the analysis. Results: Mean IMT of internal carotid arteries was increased with increasing BMI. Mean IMT was significantly higher in obese subjects compared with normal-weight (p < 0.01) and underweight (p < 0.001) subjects. Mean IMT was significantly higher in overweight subjects compared with normal-weight ones (p < 0.05). Furthermore, multivariate regression analysis in obese subjects revealed that fasting serum glucose was independently associated with IMT. Discussion: Obesity may be an important factor for carotid atherosclerosis, and at least some of the effects of obesity are independent of the BP levels. Fasting serum glucose levels in obese subjects may play an important role in carotid atherosclerosis.
引用
收藏
页码:1708 / 1715
页数:8
相关论文
共 40 条
  • [1] CAROTID-ARTERY WALL INTIMA-MEDIA THICKNESS IS ASSOCIATED WITH INSULIN-MEDIATED GLUCOSE DISPOSAL IN MEN AT HIGH AND LOW CORONARY RISK
    AGEWALL, S
    FAGERBERG, B
    ATTVALL, S
    WENDELHAG, I
    URBANAVICIUS, V
    WIKSTRAND, J
    [J]. STROKE, 1995, 26 (06) : 956 - 960
  • [2] [Anonymous], 1998, NIH PUBLICATION
  • [3] COMMON CAROTID INTIMA-MEDIA THICKNESS AND LOWER-EXTREMITY ARTERIAL ATHEROSCLEROSIS - THE ROTTERDAM STUDY
    BOTS, ML
    HOFMAN, A
    GROBBEE, DE
    [J]. ARTERIOSCLEROSIS AND THROMBOSIS, 1994, 14 (12): : 1885 - 1891
  • [4] CARDIOVASCULAR DETERMINANTS OF CAROTID-ARTERY DISEASE - THE ROTTERDAM ELDERLY STUDY
    BOTS, ML
    BRESLAU, PJ
    BRIET, E
    DEBRUYN, AM
    VANVLIET, HHDM
    VANDENOUWELAND, FA
    DEJONG, PTVM
    HOFMAN, A
    GROBBEE, DE
    [J]. HYPERTENSION, 1992, 19 (06) : 717 - 720
  • [5] Chalmers J, 1999, J HYPERTENS, V17, P151
  • [6] PRAVASTATIN, LIPIDS, AND ATHEROSCLEROSIS IN THE CAROTID ARTERIES (PLAC-II)
    CROUSE, JR
    BYINGTON, RP
    BOND, MG
    ESPELAND, MA
    CRAVEN, TE
    SPRINKLE, JW
    MCGOVERN, ME
    FURBERG, CD
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1995, 75 (07) : 455 - 459
  • [7] Metabolic syndrome in relation to structure and function of large arteries:: A predominant effect of blood pressure -: A report from the SU.VI.MAX. vascular study
    Czernichow, S
    Bertrais, S
    Blacher, J
    Oppert, JM
    Galan, P
    Ducimetière, P
    Hercberg, S
    Safar, M
    Zureik, M
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 2005, 18 (09) : 1154 - 1160
  • [8] Body mass index, abdominal adiposity and blood pressure: consistency of their association across developing and developed countries
    Doll, S
    Paccaud, F
    Bovet, P
    Burnier, M
    Wietlisbach, V
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2002, 26 (01) : 48 - 57
  • [9] Noninvasive tests of vascular function and structure: Why and how to perform them
    Fathi, R
    Marwick, TH
    [J]. AMERICAN HEART JOURNAL, 2001, 141 (05) : 694 - 703
  • [10] Overweight and obesity in the United States: prevalence and trends, 1960-1994
    Flegal, KM
    Carroll, MD
    Kuczmarski, RJ
    Johnson, CL
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 1998, 22 (01) : 39 - 47