Expression of fatty acid-binding protein-4 in gastrointestinal stromal tumors and its significance for prognosis

被引：8
作者：
Zang, Wei-Jie [1 ,2 ,3 ]
Wang, Zi-Niu [3 ]
Hu, Yi-Lin [1 ]
Huang, Hua [4 ]
Ma, Peng [1 ]
机构：
[1] Nantong Univ, Dept Gastrointestinal Surg, Affiliated Hosp, 20 Xisi St, Nantong 226001, Jiangsu, Peoples R China
[2] Nantong Univ, Affiliated Hosp, Dept Clin Biobank, Nantong, Peoples R China
[3] Nantong Univ, Med Sch, Nan Tong, Peoples R China
[4] Nantong Univ, Dept Pathol, Affiliated Hosp, 20 Xisi St, Nantong 226001, Jiangsu, Peoples R China
来源：
JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2021年 / 35卷 / 11期
关键词：
FABP4; GISTs; malignant; phenotype; prognosis; TISSUE-SPECIFIC FUNCTIONS; INTERFERENCE; PROGRESSION; ADIPOCYTES; INHIBITOR; SURVIVAL; SYNTHASE; ENERGY; FABPS;
D O I：
10.1002/jcla.24017
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Background Fatty acid-binding proteins (FABPs) have been found to be involved in tumorigenesis and development. However, the role of FABP4, a member of the FABPs, in GISTs (Gastrointestinal stromal tumors) remains unclear. This study aimed to investigate the expression of FABP4 and its prognostic value in GISTs. Methods FABP4 expression in 125 patients with GISTs was evaluated by immunohistochemical analysis of tissue microarrays. The relationship between FABP4 expression and clinicopathological features and prognosis of GISTs was analyzed. Results Multiple logistic regression analysis showed that expression of FABP4 correlated with tumor size and mitotic index. Furthermore, FABP4 level, tumor size, mitotic index, and high AFIP-Miettinen risk were independent prognostic factors in GISTs. The Kaplan-Meier survival curve showed that the 5-year survival rate of patients with high-FABP4 expression GISTs was lower. Conclusions These results suggested that high-FABP4 expression might be a marker of malignant phenotype of GISTs and poor prognosis.
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页数：7
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