Synthetic polymers for biopharmaceutical delivery

被引：41

作者：

Magnusson, Johannes Pall ^{[1
]}

Saeed, Aram Omer ^{[1
]}

Fernandez-Trillo, Francisco ^{[1
]}

Alexander, Cameron ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharm, Nottingham NG7 RD, England

来源：

POLYMER CHEMISTRY | 2011年 / 2卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

HUMAN GROWTH-HORMONE; LIVING RADICAL POLYMERIZATION; RING-OPENING POLYMERIZATION; SITE-SPECIFIC PEGYLATION; PROTEIN DISULFIDE BONDS; BOVINE SERUM-ALBUMIN; DRUG-DELIVERY; POLYETHYLENE-GLYCOL; PLASMID DNA; PLGA NANOPARTICLES;

D O I：

10.1039/c0py00210k

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The increasing complexity of biological molecules being developed for medical applications requires more sophisticated carrier materials to take these potent but delicate therapeutics to in vivo targets. Recent advances in polymer synthesis chemistries are enabling carrier vehicles of greater sophistication in architecture and function to be prepared. In this outline review, the application of polymer chemistries to protein and nucleic acid therapeutics are considered.

引用

页码：48 / 59

页数：12

共 132 条

[21] Polypeptide-polymer bioconjugates [J].

Canalle, Luiz A. ;

Lowik, Dennis W. P. M. ;

van Hest, Jan C. M. .

CHEMICAL SOCIETY REVIEWS, 2010, 39 (01) :329-353

[22] Influence of formulation parameters on the characteristics of poly(D,L-lactide-co-glycolide) microspheres containing poly(L-lysine) complexed plasmid DNA [J].

Capan, Y ;

Woo, BH ;

Gebrekidan, S ;

Ahmed, S ;

DeLuca, PP .

JOURNAL OF CONTROLLED RELEASE, 1999, 60 (2-3) :279-286

[23] Stability of poly(L-lysine)-complexed plasmid DNA during mechanical stress and DNase I treatment [J].

Capan, Y ;

Woo, BH ;

Gebrekidan, S ;

Ahmed, S ;

DeLuca, PP .

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 1999, 4 (04) :491-498

[24] Polymerization of lactide with zinc and magnesium β-diiminate complexes:: Stereocontrol and mechanism [J].

Chamberlain, BM ;

Cheng, M ;

Moore, DR ;

Ovitt, TM ;

Lobkovsky, EB ;

Coates, GW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (14) :3229-3238

[25] MODIFICATION OF CD4 IMMUNOADHESIN WITH MONOMETHOXYPOLY(ETHYLENE GLYCOL) ALDEHYDE VIA REDUCTIVE ALKYLATION [J].

CHAMOW, SM ;

KOGAN, TP ;

VENUTI, M ;

GADEK, T ;

HARRIS, RJ ;

PEERS, DH ;

MORDENTI, J ;

SHAK, S ;

ASHKENAZI, A .

BIOCONJUGATE CHEMISTRY, 1994, 5 (02) :133-140

[26] Differences in cytotoxicity of poly(PEGA)s synthesized by reversible addition-fragmentation chain transfer polymerization [J].

Chang, Chien-Wen ;

Bays, Emmanuelle ;

Tao, Lei ;

Alconcel, Steevens N. S. ;

Maynard, Heather D. .

CHEMICAL COMMUNICATIONS, 2009, (24) :3580-3582

[27] Development of poly-(D,L-lactide-coglycolide) microsphere formulations containing recombinant human vascular endothelial growth factor to promote local angiogenesis [J].

Cleland, JL ;

Duenas, ET ;

Park, A ;

Daugherty, A ;

Kahn, J ;

Kowalski, J ;

Cuthbertson, A .

JOURNAL OF CONTROLLED RELEASE, 2001, 72 (1-3) :13-24

[28] Stable formulations of recombinant human growth hormone and interferon-gamma for microencapsulation in biodegradable microspheres [J].

Cleland, JL ;

Jones, AJS .

PHARMACEUTICAL RESEARCH, 1996, 13 (10) :1464-1475

[29] Synthetic and biological polymers-merging the interface [J].

Cunliffe, D ;

Pennadam, S ;

Alexander, C .

EUROPEAN POLYMER JOURNAL, 2004, 40 (01) :5-25

[30] PRIM:: Proximity imaging of green fluorescent protein-tagged polypeptides [J].

De Angelis, DA ;

Miesenböck, G ;

Zemelman, BV ;

Rothman, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12312-12316

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