Synthetic polymers for biopharmaceutical delivery

被引：41
作者：
Magnusson, Johannes Pall [1 ]
Saeed, Aram Omer [1 ]
Fernandez-Trillo, Francisco [1 ]
Alexander, Cameron [1 ]
机构：
[1] Univ Nottingham, Sch Pharm, Nottingham NG7 RD, England
来源：
POLYMER CHEMISTRY | 2011年 / 2卷 / 01期
基金：
英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;
关键词：
HUMAN GROWTH-HORMONE; LIVING RADICAL POLYMERIZATION; RING-OPENING POLYMERIZATION; SITE-SPECIFIC PEGYLATION; PROTEIN DISULFIDE BONDS; BOVINE SERUM-ALBUMIN; DRUG-DELIVERY; POLYETHYLENE-GLYCOL; PLASMID DNA; PLGA NANOPARTICLES;
D O I：
10.1039/c0py00210k
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The increasing complexity of biological molecules being developed for medical applications requires more sophisticated carrier materials to take these potent but delicate therapeutics to in vivo targets. Recent advances in polymer synthesis chemistries are enabling carrier vehicles of greater sophistication in architecture and function to be prepared. In this outline review, the application of polymer chemistries to protein and nucleic acid therapeutics are considered.
引用
收藏
页码：48 / 59
页数：12
相关论文
共 132 条
[1]  
Abraham S, 2004, P ANN INT IEEE EMBS, V26, P5036
[2]  
ABUCHOWSKI A, 1977, J BIOL CHEM, V252, P3578
[3]   Cellular uptake of DNA block copolymer micelles with different shapes [J].
Alemdaroglu, Fikri E. ;
Alemdaroglu, N. Ceren ;
Langguth, Peter ;
Herrmann, Andreas .
MACROMOLECULAR RAPID COMMUNICATIONS, 2008, 29 (04) :326-329
[4]   DNA multiblock copolymers [J].
Alemdaroglu, Fikri E. ;
Safak, Meryem ;
Wang, Jie ;
Berger, Ruediger ;
Herrmann, Andreas .
CHEMICAL COMMUNICATIONS, 2007, (13) :1358-1359
[5]  
Anderson WF, 1998, NATURE, V392, P25
[6]   PLGA microspheres containing plasmid DNA: Preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization [J].
Ando, S ;
Putnam, D ;
Pack, DW ;
Langer, R .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1999, 88 (01) :126-130
[7]   IN-VIVO TRANSFER AND EXPRESSION OF A HUMAN EPIDERMAL GROWTH-FACTOR GENE ACCELERATES WOUND REPAIR [J].
ANDREE, C ;
SWAIN, WF ;
PAGE, CP ;
MACKLIN, MD ;
SLAMA, J ;
HATZIS, D ;
ERIKSSON, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (25) :12188-12192
[8]   Rational design of a potent, long-lasting form of interferon:: A 40 kDa branched polyethylene glycol-conjugated interferon α-2a for the treatment of hepatitis C [J].
Bailon, P ;
Palleroni, A ;
Schaffer, CA ;
Spence, CL ;
Fung, WJ ;
Porter, JE ;
Ehrlich, GK ;
Pan, W ;
Xu, ZX ;
Modi, MW ;
Farid, A ;
Berthold, W .
BIOCONJUGATE CHEMISTRY, 2001, 12 (02) :195-202
[9]   PLGA nanoparticles in drug delivery: The state of the art [J].
Bala, I ;
Hariharan, S ;
Kumar, MNVR .
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2004, 21 (05) :387-422
[10]   Site-specific PEGylation of protein disulfide bonds using a three-carbon bridge [J].
Balan, Sibu ;
Choi, Ji-won ;
Godwin, Antony ;
Teo, Ian ;
Laborde, Carlos M. ;
Heidelberger, Sibylle ;
Zloh, Mire ;
Shaunak, Sunil ;
Brocchini, Steve .
BIOCONJUGATE CHEMISTRY, 2007, 18 (01) :61-76
12345678910