Biological adhesive based on carboxymethyl chitin derivatives and chitin nanofibers

被引:90
作者
Azuma, Kazuo [1 ]
Nishihara, Masahiro [1 ]
Shimizu, Haruki [2 ]
Itoh, Yoshiki [2 ]
Takashima, Osamu [3 ]
Osaki, Tomohiro [1 ]
Itoh, Norihiko [1 ]
Imagawa, Tomohiro [1 ]
Murahata, Yusuke [1 ]
Tsuka, Takeshi [1 ]
Izawa, Hironori [2 ]
Ifuku, Shinsuke [2 ]
Minami, Saburo [1 ]
Saimoto, Hiroyuki [2 ]
Okamoto, Yoshiharu [1 ]
Morimoto, Minoru [4 ]
机构
[1] Tottori Univ, Dept Vet Clin Med, Tottori 6808533, Japan
[2] Tottori Univ, Grad Sch Engn, Tottori 6808533, Japan
[3] Tottori Prefectural Police HQ, Sci Crime Lab, Tottori 6800911, Japan
[4] Tottori Univ, Res Ctr Biosci & Technol, Div Instrumental Anal, Tottori 6808550, Japan
关键词
Chitin; 2-Hydroxy-3-methacryloyloxypropylated carboxymethyl chitin; Adhesion; Chitin nanofiber; PHOTOCROSSLINKABLE CHITOSAN; IN-VITRO; FIBROBLASTS; PROLIFERATION; BIOADHESIVES; TOXICITY; SEALANTS; GELATIN; SURFACE;
D O I
10.1016/j.biomaterials.2014.11.043
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Novel biological adhesives made from chitin derivatives were prepared and evaluated for their adhesive properties and biocompatibility. Chitin derivatives with acrylic groups, such as 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin), were synthesized and cured by the addition of an aqueous hydrogen peroxide solution as a radical initiator. The adhesive strength of HMA-CM-chitin increased when it was blended with chitin nanofibers (CNFs) or surface-deacetylated chitin nanofibers (S-DACNFs). HMA-CM-chitin/CNFs or HMA-CM-chitin/S-DACNFs have almost equal adhesive strength compared to that of a commercial cyanoacrylate adhesive. Moreover, quick adhesion and induction of inflammatory cells migration were observed in HMA-CM-chitin/CNF and HMA-CM-chitin/S-DACNF. These findings indicate that the composites prepared in this study are promising materials as new biological adhesives. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:20 / 29
页数:10
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